ATP6V1B1 and SUV39H1

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		ATP6V1B1	SUV39H1
Description		ATPase H+ transporting V1 subunit B1	SUV39H1 histone lysine methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Proton Transmembrane Transporter Activity Protein-containing Complex Binding Proton-transporting ATPase Activity, Rotational Mechanism	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity
	Biological Process	Ossification Renal Water Homeostasis Renal Sodium Ion Transport Prostaglandin Metabolic Process Monoatomic Ion Transport Regulation Of PH Vacuolar Acidification Sensory Perception Of Sound Regulation Of Gene Expression Regulation Of Macroautophagy Adult Behavior Renal Sodium Excretion Olfactory Behavior Inner Ear Morphogenesis PH Reduction ATP Metabolic Process Chloride Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Vacuolar Proton-transporting V-type ATPase Complex Assembly Renal Tubular Secretion Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs		Tiludronic acid
Diseases		Distal renal tubular acidosis (RTA type 1)
GWAS		Acne (severe) ( 24927181) Urate levels ( 31578528)
Interacting Genes		5 interacting genes: ACTN4 KDM1A NHERF1 STX1A SUV39H1	137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9
Entrez ID		525	6839
HPRD ID		01887	02221
Ensembl ID		ENSG00000116039	ENSG00000101945
Uniprot IDs		P15313	O43463
PDB IDs			3MTS
Enriched GO Terms of Interacting Partners?		Nucleoside Binding Transmembrane Transporter Binding Organelle Localization Muscle Cell Development Positive Regulation Of Sodium:proton Antiporter Activity Protein-containing Complex Regulation Of Sodium Ion Transport Identical Protein Binding Myosin Head/neck Binding Amide Transport Peptide Transport Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex ENoSc Complex Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Establishment Of Organelle Localization Vesicle Transport Along Actin Filament ATP-dependent Protein Binding Endomembrane System Response To Gravity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Chloride Channel Inhibitor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity RDNA Heterochromatin Formation Regulation Of DNA Repair RDNA Heterochromatin Microvillus Organization Regulation Of Cellular Component Size Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import	Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity
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