ATP6V1B1 and ACTN4

Number of citations of the paper that reports this interaction (PMID 10915794)
32

Data Source:
HPRD (in vivo)

		ATP6V1B1	ACTN4
Gene Name		ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	actinin, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microvillus Endomembrane System Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase, V1 Domain Extracellular Vesicular Exosome	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Hydrogen Ion Transmembrane Transporter Activity Hydrolase Activity, Acting On Acid Anhydrides, Catalyzing Transmembrane Movement Of Substances Protein Complex Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Ossification Cellular Iron Ion Homeostasis Regulation Of PH Excretion Sensory Perception Of Sound Insulin Receptor Signaling Pathway ATP Hydrolysis Coupled Proton Transport Proton Transport Transferrin Transport Inner Ear Morphogenesis PH Reduction ATP Metabolic Process Interaction With Host Calcium Ion Homeostasis Transmembrane Transport Phagosome Maturation	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Heart rate ( 23583979)
Protein-Protein Interactions		5 interactors: ACTN4 KDM1A SLC9A3R1 STX1A SUV39H1	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		525	81
HPRD ID		01887	05222
Ensembl ID		ENSG00000116039
Uniprot IDs		P15313	O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium:proton Antiporter Activity Regulation Of Proton Transport Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Organelle Organization Acid Secretion Regulation Of Sodium Ion Transport Secretion Renal Phosphate Ion Absorption Regulation Of Primitive Erythrocyte Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Localization To Tight Junction Positive Regulation Of Pinocytosis Positive Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Cellular Component Movement Response To Abiotic Stimulus Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Histone H3-K9 Dimethylation Negative Regulation Of Sodium Ion Transmembrane Transport Response To Hypoxia Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Protein Localization To Cell Junction Histone H3-K4 Demethylation Carboxylic Acid Transport Organic Acid Transport Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Phospholipase C-activating Dopamine Receptor Signaling Pathway Exocytosis Positive Regulation Of Megakaryocyte Differentiation Bile Acid Secretion Regulation Of Apoptotic Process Synaptic Vesicle Fusion To Presynaptic Membrane Histone H3-K9 Trimethylation Regulation Of Vesicle-mediated Transport Positive Regulation Of Hormone Biosynthetic Process Peptidyl-lysine Dimethylation Oligopeptide Transport Regulation Of Cell Death Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Sodium Ion Transport Renal Absorption	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?			1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?			1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?