TAF1B and RRM2

Data Source: HiPPIP (Novel)

		TAF1B	RRM2
Name		TATA-box binding protein associated factor, RNA polymerase I subunit B	ribonucleotide reductase regulatory subunit M2
Structure		No pdb structure
GO Annotations	Cellular Component	RNA Polymerase I Transcription Regulator Complex Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus RNA Polymerase I Core Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Zinc Ion Binding TBP-class Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs		None	Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690 ) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Egg allergy (maternal genetic effects) ( 29489655 ) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Prostate cancer ( 23535732 )	Kidney function decline traits ( 25493955 ) Prostate cancer ( 23535732 )
Novel Interactors		1 novel interactors: RRM2	10 novel interactors: ASAP2 BARX1 GCG ITSN2 LAPTM4A LPIN1 MGAT4A NPBWR2 ST3GAL3 TAF1B
Interacting Genes		26 interacting genes: ACADVL APP CALR EP300 ESR1 H2AC20 H2BC21 H3C1 H4C1 MEOX2 MYC NAPB NEDD4 NEDD4L PGR RRN3 RXRA SRPK1 TAF1A TAF1C TBP THAP7 TP53 TRB TRIM24 UBTF	10 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53 USP12
Entrez ID		9014	6241
HPRD ID		05363	01587
Ensembl ID		ENSG00000115750	ENSG00000171848
Uniprot IDs		Q53T94	P31350
PDB IDs		Not available	2UW2 3OLJ 3VPM 3VPN 3VPO
GO Terms Enriched among Interactors		DNA Binding DNA-templated Transcription Nucleobase-containing Compound Biosynthetic Process Protein-containing Complex Organization Transcription By RNA Polymerase II Protein-DNA Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Chromatin Organization Nucleoplasm Protein-containing Complex Assembly Chromatin RNA Polymerase Transcription Factor SL1 Complex RNA Polymerase I General Transcription Initiation Factor Activity RNA Metabolic Process Transcription Preinitiation Complex Assembly Macromolecule Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Protein-containing Complex Transcription Initiation At RNA Polymerase I Promoter Nucleus Chromatin Remodeling Nuclear Receptor-mediated Signaling Pathway Transcription Coregulator Binding Estrogen Response Element Binding Transcription Coactivator Binding Regulation Of Signal Transduction By P53 Class Mediator Transcription By RNA Polymerase I Enzyme Binding Euchromatin Core Promoter Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Hormone-mediated Signaling Pathway Nucleic Acid Metabolic Process Cellular Component Assembly Epigenetic Regulation Of Gene Expression Nuclear Steroid Receptor Activity Regulation Of MiRNA Transcription DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Initiation Structural Constituent Of Chromatin Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To UV Regulation Of MiRNA Metabolic Process	Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator