CBFB

Description		core-binding factor subunit beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Core-binding Factor Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lymphocyte Differentiation Myeloid Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Definitive Hemopoiesis
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation RUNX2 regulates chondrocyte maturation RUNX2 regulates bone development RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in differentiation of myeloid cells Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Mean corpuscular hemoglobin ( 27863252)
Interacting Genes		9 interacting genes: CBFA2T2 CHGB CHRM5 COPRS RAB2A RNF7 RUNX1 RUNX2 RUNX3
Entrez ID		865
HPRD ID		00418
Ensembl ID		ENSG00000067955
Uniprot IDs		Q13951
PDB IDs		1CL3 1E50 1H9D 4N9F 6NIL 6P59 6VGD 6VGE 6VGG 8CX0 8CX1 8CX2 8E40 8FVI 8FVJ 8H0I 8J62 8SZK
Enriched GO Terms of Interacting Partners?		Core-binding Factor Complex Chondrocyte Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Peripheral Nervous System Neuron Development Ossification Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Hemopoiesis Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Transcription Corepressor Binding Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Ligamentous Ossification Neuron Differentiation Stem Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Activation Osteoblast Fate Commitment Negative Regulation Of Focal Adhesion Disassembly Positive Regulation Of Cell Adhesion Negative Regulation Of Hemopoiesis Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Cardiac Muscle Tissue Regeneration NEDD8 Ligase Activity Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of T Cell Activation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Phosphatidylinositol Dephosphorylation NEDD8 Transferase Activity Negative Regulation Of DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Leukocyte Cell-cell Adhesion Phosphocreatine Biosynthetic Process Negative Regulation Of Lymphocyte Activation Neuron Development Negative Regulation Of RNA Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth Cell Differentiation DNA-binding Transcription Factor Binding Response To Sodium Phosphate DNA-binding Transcription Factor Activity
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