CBFB and CBFA2T2

Number of citations of the paper that reports this interaction (PMID 9447981)
33

Data Source:
HPRD (in vivo, in vitro)

		CBFB	CBFA2T2
Gene Name		core-binding factor, beta subunit	core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane	Nucleus
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Definitive Hemopoiesis	Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CBFA2T2 CHGB COPRS CUL5 RAB2A RNF7 RUNX1 RUNX2 RUNX3	23 interactors: APP ATN1 ATXN1L CBFA2T3 CBFB FBXL19 GTF2E1 ID3 LBP MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 PDP1 PRDM14 RERE RUNX1 SIN3A TAL2 TCP1 WDYHV1 ZNF652
Entrez ID		865	9139
HPRD ID		00418	04721
Ensembl ID		ENSG00000067955	ENSG00000078699
Uniprot IDs		Q13951	O43439
PDB IDs		1CL3 1E50 1H9D
Enriched GO Terms of Interacting Partners?		Peripheral Nervous System Neuron Development Hair Follicle Morphogenesis Epidermis Morphogenesis Skin Morphogenesis Chondrocyte Differentiation Hair Follicle Development Hair Cycle Process Hair Cycle Peripheral Nervous System Development Skeletal System Development Positive Regulation Of Progesterone Secretion Regulation Of Cell Proliferation Regulation Of Progesterone Secretion Cell Maturation Regulation Of Hair Follicle Cell Proliferation Tissue Development Intrinsic Apoptotic Signaling Pathway Cartilage Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Skin Development Negative Regulation Of Granulocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Connective Tissue Development Epidermis Development Protein Neddylation Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-R3 Methylation Osteoblast Fate Commitment Regulation Of Female Gonad Development Regulation Of Cellular Process Epithelium Development Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Response To Redox State Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Hematopoietic Stem Cell Proliferation Apoptotic Signaling Pathway Regulation Of Odontogenesis Of Dentin-containing Tooth System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Interferon-gamma Production Histone Arginine Methylation Regulation Of RNA Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Multicellular Organismal Development Nitrogen Compound Metabolic Process Biosynthetic Process Organ Development Definitive Hemopoiesis Central Nervous System Development Developmental Process System Development Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Forebrain Development DNA-templated Transcription, Initiation Metabolic Process Embryo Development Negative Regulation Of Cellular Metabolic Process Myeloid Cell Differentiation Thalamus Development In Utero Embryonic Development Nervous System Development Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin inv issues leukaemia mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Difference) ?		abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin inv issues leukaemia mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Intersection) ?