ARHGEF15 and EPHA4

Number of citations of the paper that reports this interaction (PubMedID 12775584)
0

Data Source:
HPRD (in vivo)

		ARHGEF15	EPHA4
Description		Rho guanine nucleotide exchange factor 15	EPH receptor A4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Cell Projection Postsynapse Glutamatergic Synapse	Cytoplasm Mitochondrial Outer Membrane Endosome Early Endosome Plasma Membrane Adherens Junction Cell Surface Postsynaptic Density Membrane Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Presynaptic Membrane Cell Projection Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Axonal Growth Cone Cell Body Synapse Postsynaptic Membrane Anchoring Junction Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Nucleotide Binding Amyloid-beta Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Postsynapse Assembly Negative Regulation Of Synapse Maturation	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Cell Adhesion Negative Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Glial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Negative Regulation Of Translation Corticospinal Tract Morphogenesis Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Organization Regulation Of GTPase Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Adhesion Negative Regulation Of Translational Initiation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Innervation Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Membraneless Organelle Assembly Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Regulation Of Synapse Pruning
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 28115744) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) Platelet distribution width ( 32888494) Total cholesterol levels ( 30275531) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cortical surface area (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels in lean individuals ( 25811787)
Interacting Genes		14 interacting genes: CDC42 CEP55 CSTPP1 DNAJC5 EPHA4 ESR1 ESRRG GORASP2 LASP1 MOB4 PIN1 PRKG1 RHOA SH3RF1	19 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF RNF5 SLA2 SRC TNS3
Entrez ID		22899	2043
HPRD ID		10535	03719
Ensembl ID		ENSG00000198844	ENSG00000116106
Uniprot IDs		A0A0S2Z547 O94989	E9PG71 P54764
PDB IDs			2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2 7OFV 9CY8
Enriched GO Terms of Interacting Partners?		Postsynapse Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Midbody Steroid Hormone Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Intracellular Signal Transduction Regulation Of Cytokinesis Glutamatergic Synapse Nuclear Receptor-mediated Signaling Pathway Establishment Of Epithelial Cell Apical/basal Polarity Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Negative Regulation Of Locomotion Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Modification Of Synaptic Structure Polarized Epithelial Cell Differentiation Negative Regulation Of Cell Motility Nuclear Steroid Receptor Activity Microtubule Polymerization Hormone-mediated Signaling Pathway Mitotic Cytokinetic Process Neuron Migration Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Establishment Of Epithelial Cell Polarity Steroid Binding Organelle Organization Negative Regulation Of Neuron Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Division Cell-cell Junction Organization Negative Regulation Of Apoptotic Process Cytokinetic Process Intracellular Signaling Cassette Cell Junction Organization Microtubule Polymerization Or Depolymerization Negative Regulation Of Signal Transduction Cell Migration Negative Regulation Of Programmed Cell Death Supramolecular Fiber Organization Positive Regulation Of Cytokinesis Substantia Nigra Development Regulation Of Amyloid-beta Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Intracellular Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Stress Fiber Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Mitotic Cleavage Furrow Formation Cytoplasm	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Activity Regulation Of Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation Neuron Projection Guidance Axon Guidance Protein Tyrosine Kinase Activity Neuron Projection Development Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phospholipase Activity Positive Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Binding Regulation Of Developmental Process Positive Regulation Of Lipase Activity Cell Projection Organization Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Phosphorylation T Cell Costimulation Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Neuron Projection Development Signal Transduction Regulation Of Cell Projection Organization Regulation Of Postsynapse Organization Positive Regulation Of MAPK Cascade Transmembrane-ephrin Receptor Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell-cell Adhesion Protein Kinase Activity Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Cell Differentiation Protein Phosphorylation
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