ARHGEF15 and LASP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ARHGEF15	LASP1
Gene Name		Rho guanine nucleotide exchange factor (GEF) 15	LIM and SH3 protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Dendrite	Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Zinc Ion Binding Ion Transmembrane Transporter Activity Actin Filament Binding
	Biological Process	Positive Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: C11orf49 CEP55 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	33 interactors: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 DAZAP2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 REL RHOXF2 SEPT3 SPRY2 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 ZBTB9 ZC2HC1A ZYX
Entrez ID		22899	3927
HPRD ID		10535	04229
Ensembl ID		ENSG00000198844	ENSG00000002834
Uniprot IDs		O94989	B4DGQ0 B4DIC4 Q14847
PDB IDs			3I35
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Steroid Hormone Mediated Signaling Pathway Fasciculation Of Motor Neuron Axon Hormone-mediated Signaling Pathway Fasciculation Of Sensory Neuron Axon Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Axon Regeneration Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth DNA-templated Transcription, Initiation Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Rho GTPase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Rho Protein Signal Transduction Corticospinal Tract Morphogenesis Vagina Development Positive Regulation Of Signal Transduction Regulation Of Axon Regeneration Uterus Development Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Cell Separation After Cytokinesis Regulation Of Rap GTPase Activity Cellular Response To Estradiol Stimulus Prostate Gland Growth Regulation Of Rac GTPase Activity Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Axonal Fasciculation Regulation Of Rap Protein Signal Transduction Regulation Of Signaling Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Organelle Organization Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Telomerase Activity Cellular Component Assembly Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Cellular Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Cellular Process Cell Cycle Process Skeletal Muscle Thin Filament Assembly Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Regulation Of Protein Metabolic Process Skeletal Myofibril Assembly Negative Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Positive Regulation Of Transferase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Regulation Of Chromosome Organization Actin Filament-based Process Positive Regulation Of Organelle Organization Blood Coagulation Mitotic Cell Cycle Process Hemostasis Chromosome Organization
Tagcloud ?			already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins
Tagcloud (Difference) ?			already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins
Tagcloud (Intersection) ?