ARHGEF15 and ESRRG

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGEF15	ESRRG
Gene Name		Rho guanine nucleotide exchange factor (GEF) 15	estrogen-related receptor gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Dendrite	Nucleoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding
	Biological Process	Positive Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Alcohol consumption ( 23743675) Cardiac hypertrophy ( 21348951) Dialysis-related mortality ( 21546767) Major depressive disorder ( 23377640) Optic disc size (cup) ( 20395239)
Protein-Protein Interactions		8 interactors: C11orf49 CEP55 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	30 interactors: APP ARHGEF15 CALM1 CCDC67 DAXX DPF2 DUT EBP EIF3I ESRRA HGS KIAA1598 KIFC3 MEOX2 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PNRC1 PNRC2 PPARGC1A PPARGC1B PROX1 SP1 SRA1 SRC SRPK1 SUMO1P1 TLE1
Entrez ID		22899	2104
HPRD ID		10535	04274
Ensembl ID		ENSG00000198844	ENSG00000196482
Uniprot IDs		O94989	B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs			1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Steroid Hormone Mediated Signaling Pathway Fasciculation Of Motor Neuron Axon Hormone-mediated Signaling Pathway Fasciculation Of Sensory Neuron Axon Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Axon Regeneration Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth DNA-templated Transcription, Initiation Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Rho GTPase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Rho Protein Signal Transduction Corticospinal Tract Morphogenesis Vagina Development Positive Regulation Of Signal Transduction Regulation Of Axon Regeneration Uterus Development Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Cell Separation After Cytokinesis Regulation Of Rap GTPase Activity Cellular Response To Estradiol Stimulus Prostate Gland Growth Regulation Of Rac GTPase Activity Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Axonal Fasciculation Regulation Of Rap Protein Signal Transduction Regulation Of Signaling Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium	Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process RNA Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Androgen Receptor Signaling Pathway Developmental Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription System Development Negative Regulation Of RNA Biosynthetic Process Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Cyclic Compound DNA-templated Transcription, Initiation Regulation Of Cellular Process Signaling Response To Hormone Steroid Metabolic Process Regulation Of Receptor Activity Cell Communication
Tagcloud ?			aging analyzing apoa apob apoe b10 block c3 c57br chr deposits evolvement glomerular glomeruli gpatch2 haplotype inbred influencing intracapillary kctd3 mapping nzw pas perilipin reponses spanning spata17 ush2a weakly
Tagcloud (Difference) ?			aging analyzing apoa apob apoe b10 block c3 c57br chr deposits evolvement glomerular glomeruli gpatch2 haplotype inbred influencing intracapillary kctd3 mapping nzw pas perilipin reponses spanning spata17 ush2a weakly
Tagcloud (Intersection) ?