DOT1L and MYCN

Number of citations of the paper that reports this interaction (PubMedID 28209620)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DOT1L	MYCN
Description		DOT1 like histone lysine methyltransferase	MYCN proto-oncogene, bHLH transcription factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Transferase Activity Histone H3K79 Methyltransferase Activity Histone Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Kinase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization Gene Expression Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding	Cartilage Condensation Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Lung Development Embryonic Digit Morphogenesis Positive Regulation Of Programmed Cell Death Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Autosome Genomic Imprinting Positive Regulation Of MiRNA Transcription Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PKMTs methylate histone lysines	Signaling by ALK Regulation of CDH1 mRNA translation by microRNAs TGFBR3 expression Regulation of PD-L1(CD274) transcription
Drugs
Diseases			Neuroblastoma Feingold syndrome
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 23563607 25282103 18391950 28552196) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878 30578418 30487518 29403010 26390057 27618448) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 30487518 27618448) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Asthma or chronic obstructive pulmonary disease ( 24993907) Basal cell carcinoma ( 25855136) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Lymphocyte count ( 32888494) Metabolite levels ( 23823483) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Wilms tumor ( 22544364)
Interacting Genes		6 interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C	20 interacting genes: CSNK2A1 CSNK2A2 DOT1L FBXW7 HUWE1 MAX MXD1 NEDD4 NMI NONO RUNX3 SIRT1 SP1 TRIM32 UBE3A UBR4 YAF2 YBX1 YEATS4 ZBTB17
Entrez ID		84444	4613
HPRD ID		10455	01278
Ensembl ID		ENSG00000104885	ENSG00000134323
Uniprot IDs		A0A8I5QL06 Q8TEK3	A0A1W2PPD9 P04198 Q9H224
PDB IDs		1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN 7BWD 7EDP 7S7E 7S7F 7XCR 7XCT	5G1X 7ZTL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Autosome Genomic Imprinting Regulation Of Cell Development DNA Binding Cell Population Proliferation Regulation Of Epithelial Cell Differentiation Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation NLRP1 Inflammasome Complex Assembly Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Histone Binding Interleukin-7-mediated Signaling Pathway ISGF3 Complex Negative Regulation By Virus Of Viral Protein Levels In Host Cell Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Negative Regulation Of Developmental Process Nucleoplasm Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Proliferation Involved In Kidney Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Protein K29-linked Ubiquitination Regulation Of Developmental Process Negative Regulation Of Astrocyte Differentiation Cellular Response To UV-B Type II Interferon-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Positive Regulation Of Gene Expression	Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macroautophagy Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Autophagy Positive Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Rhythmic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Modification By Small Protein Conjugation Protein Polyubiquitination Regulation Of Cell Cycle Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction DNA Repair Mad-Max Complex DNA Damage Response Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Catabolic Process Negative Regulation Of Signaling Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process
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