DOT1L

Gene Name		DOT1-like histone H3K79 methyltransferase
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Gene Ontology Annotations	Cellular Component	Nucleus
	Molecular Function	DNA Binding Protein Binding Transcription Factor Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific)
	Biological Process	Chromatin Silencing Histone H3-K79 Methylation Regulation Of JAK-STAT Cascade Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 23563607 18391950) Osteoarthritis ( 22566624)
Protein-protein Interactions		4 interactors: HIST3H3 MLLT10 MLLT6 STAT1
Entrez ID		84444
HPRD ID		10455
Ensembl ID		ENSG00000104885
Uniprot IDs		Q8TEK3
PDB IDs		1NW3 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macrophage Fusion Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesenchymal Cell Differentiation Involved In Kidney Development Cell Proliferation Involved In Metanephros Development Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Cell Differentiation Involved In Metanephros Development Cellular Response To Interferon-beta Cell Proliferation Involved In Kidney Development Mesenchymal Cell Proliferation Metanephric Mesenchyme Development Response To Interferon-beta Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Growth Hormone Cell Differentiation Involved In Kidney Development Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mesenchymal Cell Proliferation Response To Exogenous DsRNA Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling JAK-STAT Cascade Positive Regulation Of Smooth Muscle Cell Proliferation
Tagcloud ?		aberrant balanced blasts catalyze considerable depending deregulated disturbed drivers histones indirectly leukemia leukemic lysine marks methylated methyltransferases mll1 oncogenic originating progenitor recurrently repressing residue setd2 tightly transformed translocations writers