SS18

Description		SS18 subunit of BAF chromatin remodeling complex
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Microtubule Cytoskeleton SWI/SNF Complex NpBAF Complex GBAF Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Cell Morphogenesis Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Intracellular Signal Transduction Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases		Synovial sarcoma
GWAS		Autoimmune thyroid disease ( 32581359) Daytime nap ( 33568662) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Mean corpuscular hemoglobin ( 32888494) Nickel levels ( 26025379) Obesity-related traits ( 23251661) Periodontitis (Mean PAL) ( 24024966) QT interval (sulfonylurea treatment interaction) ( 27958378) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Toenail selenium levels ( 25343990)
Interacting Genes		9 interacting genes: EP300 FUS GRB2 H3-3A MLLT10 NFKBID RBM14 SMARCA2 SMARCA4
Entrez ID		6760
HPRD ID		02559
Ensembl ID		ENSG00000141380
Uniprot IDs		B4DLD3 B4DR34 Q15532 Q4VAX0
PDB IDs		7VRB
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Transcription Coactivator Activity Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Differentiation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Cell Adhesion Transcription Initiation-coupled Chromatin Remodeling Regulation Of T Cell Differentiation Chromatin Binding Regulation Of Cell-cell Adhesion Nucleosome Array Spacer Activity Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Regulation Of Lymphocyte Differentiation Regulation Of Organelle Organization Regulation Of Cell Activation Chromatin Remodeling BBAF Complex Positive Regulation Of Double-strand Break Repair Positive Regulation Of T-helper 17 Cell Differentiation NpBAF Complex GBAF Complex Regulation Of Cell Adhesion Chromatin Organization NBAF Complex Host-mediated Activation Of Viral Transcription Regulation Of Immune System Process Activation Of Immune Response Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Hemopoiesis Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Cell Development Regulation Of Double-strand Break Repair Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Histone Binding Nuclear Androgen Receptor Binding Positive Regulation Of T-helper Cell Differentiation
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