HPCA and UQCRB

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HPCA	UQCRB
Name		hippocalcin	ubiquinol-cytochrome c reductase binding protein
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III Respiratory Chain Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Cellular Respiration
Pathways		None	Respiratory electron transport Complex III assembly Complex III assembly
Drugs		None	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin 5-Heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		None	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Daytime nap ( 33568662 )	Huntington's disease progression ( 28642124 )
Interacting Genes		17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2	9 interacting genes: ACAP1 ACCS HPCA HSPB1 LRRK2 MAGEA1 MAGEA4 MAGEB4 ZSWIM7
Entrez ID		3208	7381
HPRD ID		00811	11770
Ensembl ID		ENSG00000121905	ENSG00000156467
Uniprot IDs		P84074	P14927
PDB IDs		5G4P 5G58 5M6C 7OWM	5XTE 5XTH 5XTI
GO Terms Enriched among Interactors		Phosphocreatine Biosynthetic Process Creatine Kinase Activity	Response To Ketamine Dendrite Cytoplasm Negative Regulation Of Protein Kinase C Signaling Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway 1-aminocyclopropane-1-carboxylate Synthase Activity Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Shu Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Perikaryon Response To Aroclor 1254 Dendritic Spine Head Regulation Of Protein Kinase C Signaling Histone Deacetylase Binding Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Regulation Of Protein Autoubiquitination Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Targeting To Mitochondrion Regulation Of Kidney Size Tangential Migration From The Subventricular Zone To The Olfactory Bulb Calcium-mediated Signaling Cellular Response To Metal Ion Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Synaptic Vesicle Recycling Cellular Response To Dopamine Intracellular Distribution Of Mitochondria Regulation Of Retrograde Transport, Endosome To Golgi Cellular Response To L-glutamate Anterograde Axonal Protein Transport Regulation Of Intrinsic Apoptotic Signaling Pathway JUN Kinase Kinase Kinase Activity Positive Regulation Of Microglial Cell Activation