HPCA and TNFRSF8

Data Source: HiPPIP (Novel)

		HPCA	TNFRSF8
Name		hippocalcin	TNF receptor superfamily member 8
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		None	TNFs bind their physiological receptors
Drugs		None	Iratumumab XmAb 2513 Brentuximab vedotin
GWAS		Daytime nap ( 33568662 )	Asthma ( 31959851 32296059 34103634 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Sum eosinophil basophil counts ( 27863252 ) Tuberculosis ( 29036319 )
Novel Interactors		12 novel interactors: APC BMP8B CSF3R DPYD E2F2 NDC80 NUDC RAE1 RUNX3 TMEM54 TNFRSF8 TUBA4A	7 novel interactors: CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 WRAP73
Interacting Genes		17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		3208	943
HPRD ID		00811	01074
Ensembl ID		ENSG00000121905	ENSG00000120949
Uniprot IDs		P84074	A5D8T4 P28908
PDB IDs		5G4P 5G58 5M6C 7OWM	1D01
GO Terms Enriched among Interactors		Phosphocreatine Biosynthetic Process Creatine Kinase Activity	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation