RFFL and RAB11FIP1

Number of citations of the paper that reports this interaction (PubMedID 30659120)
0

Data Source:
BioGRID (enzymatic study)

		RFFL	RAB11FIP1
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	RAB11 family interacting protein 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane	Cytoplasm Endosome Cytosol Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Transport Regulated Exocytosis Negative Regulation Of Adiponectin Secretion
Pathways		Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Axial length ( 24144296)
Interacting Genes		24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	6 interacting genes: RAB11A RAB25 RAB4A RFFL SNCA TRIM21
Entrez ID		117584	80223
HPRD ID		11489	09787
Ensembl ID		ENSG00000092871	ENSG00000156675
Uniprot IDs		Q8WZ73	Q6WKZ4
PDB IDs		1Y02	4D0G
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination	Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial Cell Migration G Protein Activity Vesicle-mediated Transport In Synapse Recycling Endosome Membrane Regulation Of Locomotion Recycling Endosome Myosin V Binding Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Membrane Regulation Of Long-term Neuronal Synaptic Plasticity Exocytosis Receptor Localization To Synapse Cytoplasmic Vesicle Regulation Of Cell Motility Regulation Of Cell Migration GTPase Activity GTP Binding Response To Desipramine Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Protein Destabilization Secretion By Cell Synaptic Vesicle Endosomal Processing Pseudopodium Membrane Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Response To Type II Interferon Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Pseudopodium Organization Secretion Establishment Of Protein Localization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Activin Receptor Activity, Type II Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Protein Localization To Cleavage Furrow
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