RFFL and USP28

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		RFFL	USP28
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	ubiquitin specific peptidase 28
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Deubiquitinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	DNA Damage Checkpoint Signaling DNA Repair Proteolysis DNA Damage Response Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Regulation of TP53 Degradation	Ub-specific processing proteases
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	43 interacting genes: ATXN3L BAP1 CDC73 CFTR CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 TTC3 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		117584	57646
HPRD ID		11489	15632
Ensembl ID		ENSG00000092871	ENSG00000048028
Uniprot IDs		Q8WZ73	A0A8V8TLZ9 B4E3L3 Q96RU2
PDB IDs		1Y02	2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK 7TUO 8HJE 8P14 8P19 8P1P 8P1Q
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination	Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Cysteine-type Deubiquitinase Activity Post-translational Protein Modification Protein Modification Process Peptidase Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Protein K48-linked Deubiquitination Cysteine-type Endopeptidase Activity Deubiquitinase Activity Hydrolase Activity DeNEDDylase Activity Protein K63-linked Deubiquitination Ubiquitin Binding Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process P53 Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Macromolecule Catabolic Process Cytosol Monoubiquitinated Protein Deubiquitination Negative Regulation Of Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of TOR Signaling Protein Ubiquitination Negative Regulation Of TOR Signaling Regulation Of DNA Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis DNA Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Ubiquitin Protein Ligase Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
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