RFFL and USP28

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		RFFL	USP28
Gene Name		ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	ubiquitin specific peptidase 28
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Recycling Endosome Membrane	Nucleus Nucleoplasm Nucleolus Protein Complex
	Molecular Function	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	DNA Damage Checkpoint DNA Repair Cellular Response To DNA Damage Stimulus Cell Proliferation Response To Ionizing Radiation Protein Deubiquitination Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		QT interval ( 19305408)
Protein-Protein Interactions		15 interactors: ATXN3 ATXN3L ESPL1 OTUB1 OTUB2 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UCHL5 USP28 USP5 USP7	33 interactors: ATXN3L BAP1 CLSPN ESPL1 JOSD1 KDM1A MDC1 NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A RFFL SENP8 STAM STAMBP TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		117584	57646
HPRD ID		11489	15632
Ensembl ID		ENSG00000092871	ENSG00000048028
Uniprot IDs		Q8WZ73	B4E3L3 Q96RU2
PDB IDs		1Y02	2LVA
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K48-linked Ubiquitination Cellular Protein Modification Process Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Repair Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Monoubiquitinated Protein Deubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization DNA Metabolic Process Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Misfolded Protein Protein K63-linked Deubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response	Protein Modification By Small Protein Removal Protein Deubiquitination Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Proteolysis Catabolic Process Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein K63-linked Deubiquitination Histone Deubiquitination Cellular Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification DNA Repair Metabolic Process Mitotic Cell Cycle Regulation Of Metabolic Process Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To DNA Damage Stimulus Chromatin Modification Negative Regulation Of Protein Metabolic Process Cellular Response To Stress Mitotic Cell Cycle Process Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromatin Organization Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Cell Cycle Process DNA Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram generating glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Difference) ?		biosynthesis boosting carefully causative defense es extend glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized	acetylcysteine antioxidants brief cyld cylindromatosis deprivation diminished dram glutaredoxin glutathione glycolysis grx2a hepg2 homolog isoform mediation menadione modulator peptidase peroxide pten ros state steady superoxide tensin tigar transfectants
Tagcloud (Intersection) ?		generating