RFFL and EHD1

Number of citations of the paper that reports this interaction (PubMedID 30659120)
0

Data Source:
BioGRID (enzymatic study)

		RFFL	EHD1
Description		ring finger and FYVE like domain containing E3 ubiquitin protein ligase	EH domain containing 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Recycling Endosome Membrane	Cytoplasm Endosome Early Endosome Lipid Droplet Plasma Membrane Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Intracellular Protein Transport Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Cell Projection Organization Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling
Pathways		Regulation of TP53 Degradation	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		24 interacting genes: ATXN3 ATXN3L CFTR EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 PRKN RAB11FIP1 SFN STAM STUB1 UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7	13 interacting genes: AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MUL1 OGT PACSIN2 RAB11FIP2 RBSN RFFL SNAP29
Entrez ID		117584	10938
HPRD ID		11489	09325
Ensembl ID		ENSG00000092871	ENSG00000110047
Uniprot IDs		Q8WZ73	A0A024R571 B2R5U3 Q9H4M9
PDB IDs		1Y02	2JQ6 2KFF 2KFG 2KFH 2KSP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Proteolysis Cysteine-type Deubiquitinase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Negative Regulation Of TOR Signaling Protein Polyubiquitination Cellular Response To Stress Regulation Of TORC1 Signaling Protein Ubiquitination Ubiquitin Binding Peptidase Activity Positive Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Complex Regulation Of Proteasomal Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Metabolic Process DNA Repair TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Ubiquitin-protein Transferase Activity Catabolic Process DNA Damage Response Regulation Of TOR Signaling Cellular Response To Topologically Incorrect Protein Macromolecule Catabolic Process Regulation Of Protein Polyubiquitination Protein Catabolic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Post-translational Protein Modification Protein Monoubiquitination	Intracellular Protein Localization Vesicle-mediated Transport Protein Transport Endosome Establishment Of Protein Localization Recycling Endosome Membrane Plasma Membrane Ciliary Pocket Membrane Protein Kinase Binding Endocytosis Golgi To Lysosome Transport Cilium Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Golgi Organization Golgi To Vacuole Transport Cytosolic Transport Membrane Establishment Of Localization In Cell Negative Regulation Of Protein Kinase C Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ciliary Membrane Cytosol Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Golgi Vesicle Transport Small GTPase Binding Intracellular Transport P53 Binding Cellular Response To Carbohydrate Stimulus Sulfur Oxidation Hippocampal Mossy Fiber Expansion Cell Projection Early Endosome Negative Regulation Of Intracellular Signal Transduction Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Intracellular Glucose Homeostasis Insulin Receptor Activity Protein O-acetylglucosaminyltransferase Activity TRAM-dependent Toll-like Receptor 4 Signaling Pathway F-actin Monooxygenase Activity Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Retrograde Transport, Endosome To Golgi Positive Regulation Of Cold-induced Thermogenesis
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