COPE and RCHY1

Number of citations of the paper that reports this interaction (PMID 17721809)
3

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		COPE	RCHY1
Gene Name		coatomer protein complex, subunit epsilon	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol COPI Vesicle Coat	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Structural Molecule Activity	P53 Binding Ubiquitin-protein Transferase Activity Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Intra-Golgi Vesicle-mediated Transport Protein Transport COPI Coating Of Golgi Vesicle Membrane Organization	Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		COPI Mediated Transport Golgi to ER Retrograde Transport	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Response to tocilizumab in rheumatoid arthritis ( 22491018)
Protein-Protein Interactions		9 interactors: ARF1 COPA COPB1 COPB2 COPG1 COPG2 EFHC2 RCHY1 TMED10	61 interactors: ADAMTSL4 AIG1 AOX1 AR ARF4 ATN1 BIRC3 C19orf80 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CYBA DCUN1D5 F7 FADS6 GFI1B GORAB HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MDM2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NL PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPLP1 RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBE2D2 UBE2D4 WDR74 ZNF160
Entrez ID		11316	25898
HPRD ID		06089	07607
Ensembl ID		ENSG00000105669	ENSG00000163743
Uniprot IDs		O14579	C7E542 E7EMC8 E7ETW5 J3KPI0 Q96PM5
PDB IDs			2JRJ 2K2C 2K2D
Enriched GO Terms of Interacting Partners?		COPI Coating Of Golgi Vesicle COPI-coated Vesicle Budding Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Vesicle Budding Vesicle Targeting, To, From Or Within Golgi Localization Within Membrane Vesicle Targeting Membrane Budding Golgi Vesicle Transport Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Membrane Organization Intracellular Protein Transport Protein Localization Establishment Of Localization In Cell Intra-Golgi Vesicle-mediated Transport Cellular Localization Cellular Protein Localization Transport Organelle Organization Pancreatic Juice Secretion Establishment Of Golgi Localization Cargo Loading Into Vesicle Golgi Localization Long Term Synaptic Depression Cellular Copper Ion Homeostasis COPII Vesicle Coating Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Beta-amyloid Formation Dendritic Spine Organization COPII-coated Vesicle Budding Copper Ion Homeostasis Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Actin Nucleation Regulation Of Defense Response To Virus By Virus Regulation Of Receptor Internalization Viral Process Protein Autoubiquitination	Signal Transduction In Response To DNA Damage DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic DNA Damage Checkpoint DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Stress Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cellular Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Ionizing Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process Cellular Response To DNA Damage Stimulus Cell Cycle Process Positive Regulation Of Metabolic Process Cell Death Death Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Response To Abiotic Stimulus Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death
Tagcloud ?		alcohol beginning behaviours binge connected coping distress drinking entering esteem gender genders graduating hazardous inactivity medical nation norwegian perceived postal predictors questionnaires religious school schools senior students surveys tension	20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination
Tagcloud (Difference) ?		alcohol beginning behaviours binge connected coping distress drinking entering esteem gender genders graduating hazardous inactivity medical nation norwegian perceived postal predictors questionnaires religious school schools senior students surveys tension	20s alters animal conserved correlatively crucial degradation display e3 establish handful homeodomain hox hoxa2 interacts ligase modes multitude pirh2 promotes proteasomal proteasome regulators reports reveal stabilization subunits ubiquitin ubiquitination
Tagcloud (Intersection) ?