COPE and CDC42EP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPE	CDC42EP3
Description		coat protein complex I subunit epsilon	CDC42 effector protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Actin Cytoskeleton Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Cytoskeletal Regulatory Protein Binding Small GTPase Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Protein Localization To Axon	Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Facial attractiveness (male raters) ( 30946739) HDL cholesterol levels in HIV infection ( 33109212) Height ( 31562340 28552196 23563607 20881960) Night sleep phenotypes ( 27126917) Rheumatoid arthritis ( 30891314) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		14 interacting genes: ARF1 CDC42 CDC42EP3 COPA COPB1 COPG1 COPG2 EFHC2 ERCC6 MBD1 RCHY1 SCYL1 TMED10 WBP2	12 interacting genes: CDC42 COPE DAPK1 LRRK1 LRRK2 MFHAS1 RHOQ SEPTIN6 SEPTIN7 SNCA SRPK1 UMPS
Entrez ID		11316	10602
HPRD ID		06089	09364
Ensembl ID		ENSG00000105669	ENSG00000163171
Uniprot IDs		M0QXB4 O14579	Q9UKI2
PDB IDs		6TZT 6U3V
Enriched GO Terms of Interacting Partners?		COPI Vesicle Coat COPI-coated Vesicle COPI-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Coat Transport Vesicle Intra-Golgi Vesicle-mediated Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Vesicle Transport Golgi Membrane Vesicle-mediated Transport Intracellular Protein Localization Intracellular Protein Transport Golgi Apparatus Structural Molecule Activity Establishment Of Golgi Localization Intracellular Transport Establishment Of Protein Localization Positive Regulation Of Pseudopodium Assembly Organelle Transport Along Microtubule Golgi Localization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Protein Transport Microtubule-based Movement Dendritic Spine Organization Transport Along Microtubule Cytoplasmic Vesicle Neuron Projection Organization Postsynapse Organization Cytoskeleton-dependent Intracellular Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Microtubule-based Transport Secretion Response To Metformin Cytoskeletal Regulatory Protein Binding Cytosol To ERGIC Protein Transport Cis-Golgi Network Protein Localization To ERGIC COPI-coated Vesicle Budding Cell Leading Edge Regulation Of Actin Filament Organization Establishment Of Organelle Localization Cleavage Furrow Ingression GBD Domain Binding Storage Vacuole Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein	GTP Binding Nucleotide Binding GBD Domain Binding GTPase Activity Regulation Of Macrophage Activation Sperm Annulus Cytoskeleton Cytoplasm Cell Division Site Septin Ring Septin Complex Response To Type II Interferon Regulation Of SNARE Complex Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Identical Protein Binding Intracellular Signal Transduction Syntaxin-1 Binding Protein Serine Kinase Activity GTP Metabolic Process Synaptic Vesicle Protein Serine/threonine Kinase Activity Phosphate-containing Compound Metabolic Process Positive Regulation Of Endocytosis Positive Regulation Of Filopodium Assembly Regulation Of Synaptic Vesicle Recycling Endocytosis Midbody Molecular Adaptor Activity Protein Kinase Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Terminal Bouton Cellular Response To Oxidative Stress Magnesium Ion Binding Regulation Of Cell Projection Assembly Positive Regulation Of Cellular Component Organization Spindle Cleavage Furrow Import Into Cell Regulation Of Filopodium Assembly Postsynapse Kinase Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Axon Terminus
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