LHX3 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX3	SH2D1A
Description		LIM homeobox 3	SH2 domain containing 1A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Regulation of expression of SLITs and ROBOs	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 20189936 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 28166213) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)
Interacting Genes		80 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL CATSPERT CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 DRC4 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LDB2 LHX1 LMX1A MAPK9 NFIA NFIB NFIC NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		8022	4068
HPRD ID		02783	02390
Ensembl ID		ENSG00000107187	ENSG00000183918
Uniprot IDs		F1T0D5 F1T0D7 F1T0D9 Q9UBR4	O60880
PDB IDs			1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II LIM Domain Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Nucleus Cell Differentiation In Spinal Cord DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Central Nervous System Neuron Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Visceral Motor Neuron Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Transcription Regulator Complex Spinal Cord Motor Neuron Differentiation Cytoskeletal Anchor Activity DNA-templated Transcription RNA Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cell Population Proliferation Regulation Of Gene Expression Cyclin Binding Pattern Specification Process Chromatin Positive Regulation Of RNA Biosynthetic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Axis Specification Glial Cell Fate Specification Actin Filament Positive Regulation Of Smoothened Signaling Pathway Neural Tube Formation Regulation Of Macromolecule Biosynthetic Process Peripheral Nervous System Neuron Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response
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