SH2D1A and CD244

Number of citations of the paper that reports this interaction (PubMedID 10358138)
0

Data Source:
BioGRID (affinity chromatography technology)

		SH2D1A	CD244
Description		SH2 domain containing 1A	CD244 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Signaling Receptor Activity MHC Class I Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Adaptive Immune Response Natural Killer Cell Activation Involved In Immune Response Immune System Process Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Innate Immune Response Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Granzyme B Production
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cell surface interactions at the vascular wall
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	5 interacting genes: ARHGEF7 CD247 CD48 LAT SH2D1B
Entrez ID		4068	51744
HPRD ID		02390	16121
Ensembl ID		ENSG00000183918	ENSG00000122223
Uniprot IDs		O60880	Q9BZW8
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response	Cell Activation Leukocyte Activation Adaptive Immune Response Lymphocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response Immune Response Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Platelet-derived Growth Factor Alpha-receptor Activity Negative Regulation Of Microtubule Nucleation Aconitate Hydratase Activity Fc-gamma Receptor III Complex Gamma-delta T Cell Receptor Complex Immune Effector Process Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Platelet-derived Growth Factor Receptor-ligand Complex TCR Signalosome
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