LHX3 and ZNF354C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LHX3	ZNF354C
Description		LIM homeobox 3	zinc finger protein 354C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Membrane Nuclear Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sprouting Angiogenesis
Pathways		Regulation of expression of SLITs and ROBOs	Generic Transcription Pathway
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 20189936 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 28166213) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		80 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL CATSPERT CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 DRC4 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LDB2 LHX1 LMX1A MAPK9 NFIA NFIB NFIC NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	7 interacting genes: CCDC6 LHX3 LHX4 LINC00624 LMO1 SRY TRIM28
Entrez ID		8022	30832
HPRD ID		02783	15785
Ensembl ID		ENSG00000107187	ENSG00000177932
Uniprot IDs		F1T0D5 F1T0D7 F1T0D9 Q9UBR4	Q86Y25
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II LIM Domain Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Nucleus Cell Differentiation In Spinal Cord DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Central Nervous System Neuron Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Visceral Motor Neuron Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Transcription Regulator Complex Spinal Cord Motor Neuron Differentiation Cytoskeletal Anchor Activity DNA-templated Transcription RNA Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cell Population Proliferation Regulation Of Gene Expression Cyclin Binding Pattern Specification Process Chromatin Positive Regulation Of RNA Biosynthetic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Axis Specification Glial Cell Fate Specification Actin Filament Positive Regulation Of Smoothened Signaling Pathway Neural Tube Formation Regulation Of Macromolecule Biosynthetic Process Peripheral Nervous System Neuron Development	Medial Motor Column Neuron Differentiation Motor Neuron Axon Guidance Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cell Differentiation In Spinal Cord Placenta Development Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Prolactin Secreting Cell Differentiation Krueppel-associated Box Domain Binding Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin-like Protein Ligase Activity Positive Regulation Of Biosynthetic Process Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Embryonic Placenta Morphogenesis DNA-binding Transcription Factor Binding Thyroid-stimulating Hormone-secreting Cell Differentiation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Male Gonad Development Spinal Cord Motor Neuron Cell Fate Specification Neuron Projection Guidance Axon Guidance Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Spinal Cord Association Neuron Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Convergent Extension Transcription Coactivator Activity DNA Binding Male Sex Determination Regulation Of Nucleobase-containing Compound Metabolic Process Suppression Of Viral Release By Host DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuroendocrine Cell Differentiation Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding SUMO Transferase Activity Genomic Imprinting Sex Determination
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