LHX3 and CITED2

Number of citations of the paper that reports this interaction (PubMedID 10593900)
0

Data Source:
HPRD (in vivo, two hybrid)

		LHX3	CITED2
Description		LIM homeobox 3	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Histone Acetyltransferase Binding SMAD Binding LBD Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Function Activator Activity
	Biological Process	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Neural Tube Formation Neural Tube Closure Liver Development Embryonic Placenta Development Vasculature Development Heart Looping Lens Morphogenesis In Camera-type Eye Hematopoietic Progenitor Cell Differentiation Leukocyte Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Outflow Tract Morphogenesis Regulation Of Animal Organ Formation Endocardial Cushion Development Ventricular Septum Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Determination Of Left/right Symmetry Central Nervous System Development Peripheral Nervous System Development Heart Development Sex Determination Cell Population Proliferation Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cranial Nerve Morphogenesis Positive Regulation Of Cell-cell Adhesion Cell Differentiation Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Granulocyte Differentiation Response To Fluid Shear Stress Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Adrenal Cortex Formation Skeletal Muscle Cell Differentiation Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Decidualization Spleen Development Thymus Development Embryonic Camera-type Eye Morphogenesis Erythrocyte Development Uterus Development Embryonic Process Involved In Female Pregnancy Bone Morphogenesis Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Heart Development Determination Of Heart Left/right Asymmetry Left/right Axis Specification Cellular Response To Growth Factor Stimulus Cellular Response To Hypoxia Cellular Senescence Positive Regulation Of Male Gonad Development
Pathways		Regulation of expression of SLITs and ROBOs	Regulation of gene expression by Hypoxia-inducible Factor TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors FOXO-mediated transcription of cell death genes
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 20189936 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 28166213) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Alanine aminotransferase levels ( 33547301) Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood trace element (Se levels) ( 23720494) Caudate volume in trauma-exposed individuals ( 29187748) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899) IgA levels ( 28628107) Mean corpuscular hemoglobin ( 28453575 19862010 28017375 20139978 23263863) Mean corpuscular volume ( 19862010 28017375 32888494 20139978 23263863 28453575) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Red blood cell traits ( 23222517) Systolic blood pressure ( 30224653) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Triglyceride levels ( 32203549) Triglycerides ( 25961943) Urate levels in lean individuals ( 25811787)
Interacting Genes		80 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL CATSPERT CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 DRC4 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LDB2 LHX1 LMX1A MAPK9 NFIA NFIB NFIC NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	11 interacting genes: CREBBP EP300 FBXL5 HIF1A LHX2 LHX3 MAPK1 TBP TFAP2A TFAP2B TFAP2C
Entrez ID		8022	10370
HPRD ID		02783	04245
Ensembl ID		ENSG00000107187	ENSG00000164442
Uniprot IDs		F1T0D5 F1T0D7 F1T0D9 Q9UBR4	A0A0A0MTM3 D9ZGF1 Q99967
PDB IDs			1P4Q 1R8U 7LVS 7QGS
Enriched GO Terms of Interacting Partners?		Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II LIM Domain Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Neuron Fate Specification Nucleus Cell Differentiation In Spinal Cord DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Central Nervous System Neuron Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Visceral Motor Neuron Differentiation Sequence-specific Double-stranded DNA Binding Nucleoplasm Transcription Regulator Complex Spinal Cord Motor Neuron Differentiation Cytoskeletal Anchor Activity DNA-templated Transcription RNA Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Cell Population Proliferation Regulation Of Gene Expression Cyclin Binding Pattern Specification Process Chromatin Positive Regulation Of RNA Biosynthetic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Axis Specification Glial Cell Fate Specification Actin Filament Positive Regulation Of Smoothened Signaling Pathway Neural Tube Formation Regulation Of Macromolecule Biosynthetic Process Peripheral Nervous System Neuron Development	Chromatin Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Formation Involved In Morphogenesis DNA Binding Animal Organ Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Histone H3K27 Acetyltransferase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity Regulation Of Primary Metabolic Process N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Chromatin Binding Regulation Of Metabolic Process Animal Organ Morphogenesis P53 Binding Transcription Regulator Complex Nucleus Cerebral Cortex Development Regulation Of Gene Expression DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process N-terminal Protein Amino Acid Acetylation Transcription By RNA Polymerase II Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Mammary Gland Epithelial Cell Proliferation Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
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