NUP107 and PPIL3

		NUP107	PPIL3
Description		nucleoporin 107	peptidylprolyl isomerase like 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity
	Biological Process	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Female Gonad Development Protein Transport MRNA Transport Nuclear Pore Complex Assembly Nephron Development	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		White blood cell count ( 20139978)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		4 interacting genes: APAF1 NUP133 NUP214 SUMO2	10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1
Entrez ID		57122	53938
HPRD ID		06356	15163
Ensembl ID		ENSG00000111581	ENSG00000240344
Uniprot IDs		P57740	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs		3CQC 3CQG 3I4R 5A9Q 7PEQ 7R5J 7R5K	1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Pore Response To G1 DNA Damage Checkpoint Signaling RNA Export From Nucleus Cytoplasmic Side Of Nuclear Pore MRNA Export From Nucleus Nuclear Pore Protein Import Into Nucleus Import Into Nucleus MRNA Transport Nuclear Export RNA Transport Apoptosome Protein Localization To Nucleus Nucleobase-containing Compound Transport Nuclear Envelope Response To DNA Damage Checkpoint Signaling Nuclear Transport Nucleocytoplasmic Transport Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Paraxial Mesoderm Development Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Nuclear Pore Outer Ring Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Establishment Of Protein Localization To Organelle Nuclear Export Signal Receptor Activity Nephron Development Striated Muscle Cell Apoptotic Process Nuclear Pore Organization Protein Tag Activity Somite Development Muscle Cell Apoptotic Process SUMO Transferase Activity Nuclear Localization Sequence Binding Poly(A)+ MRNA Export From Nucleus Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Intracellular Protein Transport Protein Export From Nucleus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Peptidyl-prolyl Cis-trans Isomerase Activity
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