PRRX2 and SOX10

Number of citations of the paper that reports this interaction (PMID 16582099)
41

Data Source:
HPRD (two hybrid)

		PRRX2	SOX10
Gene Name		paired related homeobox 2	SRY (sex determining region Y)-box 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Transcription, DNA-templated Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Artery Morphogenesis Cartilage Development	In Utero Embryonic Development Neural Crest Cell Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Positive Regulation Of Gliogenesis Melanocyte Differentiation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SOX10	28 interactors: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		51450	6663
HPRD ID		05244	03752
Ensembl ID		ENSG00000167157	ENSG00000100146
Uniprot IDs		Q99811	B4DV62 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?		Enteric Nervous System Development Positive Regulation Of Neuroblast Proliferation Melanocyte Differentiation Autonomic Nervous System Development Neuroepithelial Cell Differentiation Neural Crest Cell Migration Regulation Of Neuroblast Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Gliogenesis Developmental Pigmentation Neural Crest Cell Development Digestive Tract Morphogenesis Positive Regulation Of Stem Cell Proliferation Oligodendrocyte Differentiation Neural Crest Cell Differentiation Regulation Of Gliogenesis Peripheral Nervous System Development Regulation Of Neural Precursor Cell Proliferation Regulation Of Stem Cell Proliferation Mesenchymal Cell Development Pigmentation Mesenchymal Cell Differentiation Digestive Tract Development Cell Maturation Negative Regulation Of Canonical Wnt Signaling Pathway Digestive System Development Ameboidal-type Cell Migration Glial Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Gliogenesis Stem Cell Development Developmental Growth	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Tissue Development Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process System Development Macromolecule Biosynthetic Process Protein Sumoylation Embryonic Morphogenesis Anatomical Structure Development Embryonic Organ Development Embryo Development Nucleobase-containing Compound Metabolic Process Multicellular Organismal Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Cellular Nitrogen Compound Metabolic Process Pattern Specification Process Embryonic Organ Morphogenesis Organ Morphogenesis Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Cell Proliferation Gland Development
Tagcloud ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx1 retina rpf1 sequence transcripts upstream yeast	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Difference) ?		abundant anterior bait cdna cloned cloning diencephalon differentiating fshbeta gland homeobox hybrid library lobe participating periods pituitary porcine pou primordium progenitor prop1 prrx1 retina rpf1 sequence transcripts upstream yeast	abundantly border commences complexity crest dimethylation distinguishing foxd3 methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox9 spatiotemporally specification stationary temporally unexpected
Tagcloud (Intersection) ?