NUP88 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		NUP88	AGTR1
Description		nucleoporin 88	angiotensin II receptor type 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol	Plasma Membrane Membrane
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS		Adult body size ( 32376654) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		5 interacting genes: AGTR1 CD82 NUP214 NUP98 TFIP11	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		4927	185
HPRD ID		03974	00107
Ensembl ID		ENSG00000108559	ENSG00000144891
Uniprot IDs		B4DP20 J3KMX1 Q99567	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		7MNI 7R5J 7R5K	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Convergent Extension Involved In Neural Plate Elongation Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission RNA Export From Nucleus Nuclear Export Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Import Into Nucleus MRNA Transport Protein Import Into Nucleus Nuclear Pore Cytoplasmic Side Of Nuclear Pore Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Biological Process Involved In Interaction With Host Convergent Extension Involved In Organogenesis RNA Transport Nuclear Pore Cytoplasmic Filaments Convergent Extension Involved In Gastrulation Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Protein Localization To Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protection From Non-homologous End Joining At Telomere Regulation Of Renal Sodium Excretion Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Telomere Localization Nuclear Envelope Nucleobase-containing Compound Transport Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Trans-synaptic Signaling, Modulating Synaptic Transmission Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Nuclear Export Signal Receptor Activity Convergent Extension Nuclear Pore Nuclear Basket Nuclear Pore Organization	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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