SIKE1 and IKBKE

Number of citations of the paper that reports this interaction (PMID 16281057)
39

Data Source:
HPRD (in vivo, two hybrid)

		SIKE1	IKBKE
Gene Name		suppressor of IKBKE 1	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane
	Molecular Function	Protein Binding	NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity
	Biological Process	Innate Immune Response	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF6 mediated IRF7 activation Innate Immune System	Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: IKBKE TBK1	21 interactors: AZI2 BIRC2 BIRC3 CDC37 CHUK FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA SIKE1 TANK TBK1 TICAM1 TRAF2 TRIM27 XIAP
Entrez ID		80143	9641
HPRD ID		07958	05442
Ensembl ID		ENSG00000052723	ENSG00000143466
Uniprot IDs		Q9BRV8	Q14164
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Negative Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Dendritic Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Immune Response I-kappaB Phosphorylation Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Type I Interferon Production Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Protein Phosphorylation Regulation Of Interferon-beta Production Defense Response NIK/NF-kappaB Signaling Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Positive Regulation Of Type I Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Immune System Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cytokine Biosynthetic Process Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation	Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Innate Immune Response Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-beta Production Response To Bacterium Intracellular Signal Transduction Regulation Of Interferon-beta Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Necrotic Cell Death Necrotic Cell Death NIK/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Signaling Type I Interferon Production Response To Virus Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Response To Other Organism Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Biotic Stimulus Defense Response To Virus Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		146a 5p adipogenic ameliorate bm cxcl12 damaged degenerative engraftment epsilon homing ikkepsilon injured jelly micrornas mir mirnome motility msc mscs osteogenic poorer property roadmap transplanted umbilical uncoupling wharton wj	accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft
Tagcloud (Difference) ?		146a 5p adipogenic ameliorate bm cxcl12 damaged degenerative engraftment epsilon homing injured jelly micrornas mir mirnome motility msc mscs osteogenic poorer property roadmap transplanted umbilical uncoupling wharton wj	accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft
Tagcloud (Intersection) ?		ikkepsilon