SIKE1 and SCOC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SIKE1	SCOC
Description		suppressor of IKBKE 1	short coiled-coil protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex	Golgi Membrane Nucleoplasm Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding	Protein Binding
	Biological Process	Negative Regulation Of Hippo Signaling	Positive Regulation Of Macroautophagy Regulation Of Protein Complex Stability
Pathways		TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Malaria ( 31844061) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C	14 interacting genes: ARL1 BFSP2 DDIT4L DOK5 FEZ1 ITSN1 KIFC3 KRT40 MAPK8 PSMC5 SCHIP1 SIKE1 TCF4 TRAPPC6A
Entrez ID		80143	60592
HPRD ID		07958	18027
Ensembl ID		ENSG00000052723	ENSG00000153130
Uniprot IDs		Q9BRV8	A0A0C4DGB0 A0A804E055 Q9UIL1
PDB IDs		6AKK 6AKL 6AKM	4BWD 7AA7
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore
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