SIKE1 and ZC2HC1C

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIKE1	ZC2HC1C
Description		suppressor of IKBKE 1	zinc finger C2HC-type containing 1C
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Hippo Signaling
Pathways		TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)	Neurociticism ( 29500382) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C	80 interacting genes: ACTMAP ACTN2 ANKS1A ARMC7 BANP BICD2 BYSL CABP5 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC85B CCDC88B CIB3 CLIC3 CRACR2A DDX6 EMILIN1 ENKD1 FAM90A1 FBXO7 FGFR1OP2 FSD2 GFAP GOLGA1 GOLGA2 GOLGA6A GPRASP2 HOOK2 HSF2BP KASH5 KAT5 KATNBL1 KIF9 KRT15 KRT20 KRT40 LMNA LMNB2 LZTS2 MAPK9 MAPRE3 MID2 MTUS2 NCKIPSD NDEL1 NDOR1 NEK6 NOXA1 NTAQ1 OSGIN1 PFDN5 PIBF1 PNMA1 POLR1C PRKAB2 PSTPIP1 RABGEF1 RAD51D RINT1 SFN SIKE1 SMARCD1 SORBS3 SPAG5 TFIP11 TNPO2 TRAF1 TRAF2 TRIM23 TRIM27 TRIM55 TRIM63 UBASH3A VPS52 ZNF655 ZNF76
Entrez ID		80143	79696
HPRD ID		07958	16607
Ensembl ID		ENSG00000052723	ENSG00000119703
Uniprot IDs		Q9BRV8	J3KMY6 Q53FD0
PDB IDs		6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore	Cytoskeleton Organization Cytoskeleton Cytoplasm Microtubule Cytoskeleton Organization Protein Binding Microtubule Microtubule-based Process Microtubule Binding Organelle Organization Identical Protein Binding Microtubule Organizing Center Intracellular Transport Structural Constituent Of Cytoskeleton Cytosol Intermediate Filament Centrosome Spindle Localization Establishment Of Localization In Cell Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Cellular Component Organization Establishment Of Organelle Localization Membraneless Organelle Assembly Cellular Localization Organelle Localization Establishment Of Spindle Orientation Intermediate Filament Cytoskeleton Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Spindle Assembly Protein Localization To Cytoskeleton Supramolecular Fiber Organization Spindle Pole Spindle Organization Intracellular Protein Localization Establishment Of Spindle Localization Positive Regulation Of Autophagy Nuclear Pore Localization Dynein Light Intermediate Chain Binding Regulation Of Autophagy Microtubule Nucleation Intermediate Filament Organization Chromosome Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole Thioesterase Binding Establishment Of Mitotic Spindle Localization Regulation Of Organelle Organization Golgi Cis Cisterna
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