SIKE1

Gene Name		suppressor of IKBKE 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Protein Binding
	Biological Process	Innate Immune Response
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF6 mediated IRF7 activation Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: IKBKE TBK1
Entrez ID		80143
HPRD ID		07958
Ensembl ID		ENSG00000052723
Uniprot IDs		Q9BRV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Negative Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Dendritic Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Immune Response I-kappaB Phosphorylation Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Type I Interferon Production Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Protein Phosphorylation Regulation Of Interferon-beta Production Defense Response NIK/NF-kappaB Signaling Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Positive Regulation Of Type I Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Immune System Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cytokine Biosynthetic Process Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation
Tagcloud ?		146a 5p adipogenic ameliorate bm cxcl12 damaged degenerative engraftment epsilon homing ikkepsilon injured jelly micrornas mir mirnome motility msc mscs osteogenic poorer property roadmap transplanted umbilical uncoupling wharton wj