SIKE1

Description		suppressor of IKBKE 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding
	Biological Process	Negative Regulation Of Hippo Signaling
Pathways		TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149)
Interacting Genes		13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C
Entrez ID		80143
HPRD ID		07958
Ensembl ID		ENSG00000052723
Uniprot IDs		Q9BRV8
PDB IDs		6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore
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