SIKE1 and STX11

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SIKE1	STX11
Description		suppressor of IKBKE 1	syntaxin 11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol FAR/SIN/STRIPAK Complex	Golgi Apparatus Plasma Membrane Endomembrane System Membrane SNARE Complex Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Small GTPase Binding	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Hippo Signaling	Intracellular Protein Transport Exocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion
Pathways		TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases			Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Age at first sexual intercourse ( 34211149)	Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		13 interacting genes: CBFA2T2 CENPQ CTAG1A CTAG1B IKBKE NTAQ1 SCOC STRN3 STX11 TBK1 TXLNA TXLNB ZC2HC1C	98 interacting genes: AIRIM APP AXIN1 AXIN2 BLOC1S6 BYSL CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A MTCL2 NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNCA SNX3 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587
Entrez ID		80143	8676
HPRD ID		07958	09231
Ensembl ID		ENSG00000052723	ENSG00000135604
Uniprot IDs		Q9BRV8	O75558
PDB IDs		6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Serine/threonine Protein Kinase Complex Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Syntaxin Binding Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore	Identical Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex SNARE Complex Assembly Protein Binding SNAP Receptor Activity SNARE Complex Synaptic Vesicle Docking Synaptic Vesicle Exocytosis SNARE Binding Regulation Of Cellular Response To Stress Regulation Of DNA Repair BLOC-1 Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Docking Establishment Of Organelle Localization Positive Regulation Of Proteolysis Positive Regulation Of Synaptic Transmission Syntaxin Binding Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of RNA Metabolic Process Transcription Coactivator Activity Neurotransmitter Transport Vesicle Fusion Membrane Fusion Long-term Synaptic Potentiation Regulation Of Gene Expression Organelle Membrane Fusion Organelle Localization Establishment Of Vesicle Localization Host-mediated Perturbation Of Symbiont Process DNA Repair-dependent Chromatin Remodeling Regulation Of DNA-templated Transcription Nuclear Androgen Receptor Binding Vesicle Organization Vesicle Docking Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Modulation Of Process Of Another Organism Microtubule-based Process Vesicle Localization Neuron Projection Nucleoplasm
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?