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CALM1 and H2AFX
Number of citations of the paper that reports this interaction (PMID
16522924
)
19
Data Source:
BioGRID
(two hybrid)
CALM1
H2AFX
Gene Name
calmodulin 1 (phosphorylase kinase, delta)
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Spindle Pole
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Spindle Microtubule
Plasma Membrane
Sarcomere
Growth Cone
Vesicle
Calcium Channel Complex
Extracellular Vesicular Exosome
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Calcium Ion Binding
Protein Binding
Adenylate Cyclase Binding
Protein Kinase Binding
Protein Domain Specific Binding
Nitric-oxide Synthase Regulator Activity
Titin Binding
Type 3 Metabotropic Glutamate Receptor Binding
Thioesterase Binding
N-terminal Myristoylation Domain Binding
Phospholipase Binding
Protein Serine/threonine Kinase Activator Activity
Phosphatidylinositol 3-kinase Binding
Ion Channel Binding
Calcium-dependent Protein Binding
Nitric-oxide Synthase Binding
Protein Phosphatase Activator Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Response To Amphetamine
Regulation Of Heart Rate
Platelet Degranulation
Detection Of Calcium Ion
Carbohydrate Metabolic Process
Glycogen Catabolic Process
Glucose Metabolic Process
Muscle Contraction
Organelle Organization
Mitochondrion Organization
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Activation Of Phospholipase C Activity
Synaptic Transmission
Blood Coagulation
Phototransduction, Visible Light
Fibroblast Growth Factor Receptor Signaling Pathway
Pathogenesis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Rhodopsin Mediated Signaling Pathway
Substantia Nigra Development
Regulation Of Rhodopsin Mediated Signaling Pathway
Platelet Activation
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Positive Regulation Of Protein Autophosphorylation
Regulation Of Cytokinesis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Fc-epsilon Receptor Signaling Pathway
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
Nitric Oxide Metabolic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Corticosterone
Response To Calcium Ion
Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Membrane Organization
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of High Voltage-gated Calcium Channel Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by GPCR
Ca-dependent events
CaM pathway
Signaling by FGFR in disease
Phospholipase C-mediated cascade
Signaling by Wnt
Platelet degranulation
Signaling by EGFRvIII in Cancer
CREB phosphorylation through the activation of Ras
PLCG1 events in ERBB2 signaling
Glucose metabolism
DAP12 signaling
Synthesis of IP3 and IP4 in the cytosol
Myoclonic epilepsy of Lafora
Response to elevated platelet cytosolic Ca2+
Glycogen storage diseases
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Activation of Ca-permeable Kainate Receptor
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Ionotropic activity of Kainate Receptors
Signaling by PDGF
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
DAP12 interactions
Glycogen breakdown (glycogenolysis)
Opioid Signalling
Activation of Kainate Receptors upon glutamate binding
Diseases associated with visual transduction
Inositol phosphate metabolism
EGFR interacts with phospholipase C-gamma
CaMK IV-mediated phosphorylation of CREB
Signaling by ERBB2
Signaling by EGFR
Signaling by VEGF
CREB phosphorylation through the activation of CaMKK
Downstream signal transduction
Calmodulin induced events
CREB phosphorylation through the activation of CaMKII
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
Transcriptional activation of mitochondrial biogenesis
Metabolism of carbohydrates
Platelet activation, signaling and aggregation
Adaptive Immune System
Transmission across Chemical Synapses
Ras activation uopn Ca2+ infux through NMDA receptor
Organelle biogenesis and maintenance
Cam-PDE 1 activation
Translocation of GLUT4 to the plasma membrane
VEGFA-VEGFR2 Pathway
DAG and IP3 signaling
CaM pathway
Inactivation, recovery and regulation of the phototransduction cascade
Metabolism of nitric oxide
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability
Activation of NMDA receptor upon glutamate binding and postsynaptic events
The phototransduction cascade
Downstream signaling of activated FGFR
DARPP-32 events
eNOS activation and regulation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Innate Immune System
Post NMDA receptor activation events
Signalling by NGF
PLC beta mediated events
Smooth Muscle Contraction
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Signaling by Overexpressed Wild-Type EGFR in Cancer
Mitochondrial biogenesis
beta-catenin independent WNT signaling
Signaling by FGFR
eNOS activation
Cam-PDE 1 activation
Ca2+ pathway
Visual phototransduction
Activation of CaMK IV
PLC-gamma1 signalling
FCERI mediated Ca+2 mobilization
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
232 interactors:
ACADM
ADCY8
ADCYAP1R1
ADD1
ADD2
AKAP5
AKAP6
AKAP9
AR
ARHGEF7
ARMC1
ASCL2
ATP2B1
ATRX
BRWD1
C11orf65
CABIN1
CALCR
CALD1
CAMK1
CAMK2G
CAMKK1
CAMKK2
CASP8AP2
CCDC14
CCNA2
CCND1
CCND2
CCNE1
CCP110
CDC37L1
CDC5L
CKMT1B
CLINT1
CLIP1
CLTB
CNGA2
CNN1
CRHR1
CSNK2A1
CSNK2A2
CSNK2B
DAPK1
DCTN2
DCUN1D1
DDAH1
DDX21
DDX5
DLG3
DMXL1
DNAJC13
DOCK11
DOCK3
DRD2
DST
EDF1
EGFR
EIF3C
ESR1
ESR2
ESRRG
EWSR1
FAM178A
FAS
FBXO9
FER
FKBP3
FKBP4
GAP43
GCLM
GJB1
GLP1R
GLP2R
GNAS
GRB7
GRIN1
GRK1
GRK4
GRK5
GRM3
GRM4
GRM5
GRM7
GTF2I
H2AFX
HERC2
HMMR
HSP90AA1
HSPA4
HTR2C
HUWE1
IMMT
INSR
IQGAP1
IQGAP2
ITGA6
ITPKA
ITPKB
KCNH1
KCNN2
KCNN3
KCNN4
KCNQ2
KCNQ3
KCNQ5
KDM5C
KIAA0020
KIAA1683
KIF1B
KRAS
LACTB
LMO7
LTF
LUC7L
LY96
LYST
MAPT
MATR3
MBIP
METAP2
MIP
MORF4L1
MYBPC1
MYCBP2
MYF5
MYF6
MYLK
MYO10
MYO7A
MYO9B
MYOD1
MYOG
NBR1
NEB
NEUROD1
NEXN
NOL7
NOS3
NR3C1
NRGN
NT5C2
OBSCN
OPALIN
OPRM1
OPTN
PAM
PCNT
PCP4
PDCD7
PDE1A
PHACTR4
PHKG1
PIK3C3
PLCD1
POLR2B
PPEF1
PPEF2
PPIL2
PRDX1
PSMD12
PSMD2
PTAFR
PTH2R
PTPRA
RAB3B
RAD23B
RALA
RALB
RANBP2
RDX
REL
RELA
RGS10
RGS2
RGS4
RIT2
RPL13A
RPL22
RPS14
RPS15A
RPS4Y1
RPS8
RRAD
RYR1
RYR2
S100B
SCAPER
SCLT1
SCN4A
SCN5A
SCTR
SEC61A1
SET
SF3B1
SLTM
SNCA
SNRPB2
SNTA1
SNX6
SPP1
SQSTM1
SRP14
SRSF5
STAG1
STIM2
STK38
STRN
STRN3
STRN4
STX8
SYK
SYNE2
SYT1
TCF3
TCF4
THOP1
TNNI2
TPT1
TRDN
TRPC3
TRPV1
TRPV4
TRPV6
TSC2
TTN
UCHL5
USP16
VIPR1
XRCC4
YBX1
YWHAE
ZBTB24
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
801
3014
HPRD ID
00241
03465
Ensembl ID
ENSG00000198668
ENSG00000188486
Uniprot IDs
B4DJ51
E7ETZ0
P62158
P16104
PDB IDs
1AJI
1CDL
1CLL
1CTR
1IWQ
1J7O
1J7P
1K90
1K93
1L7Z
1LVC
1NKF
1PK0
1S26
1SK6
1SW8
1WRZ
1XFU
1XFV
1XFW
1XFX
1XFY
1XFZ
1Y6W
1YR5
1YRT
1YRU
1ZOT
1ZUZ
2BE6
2F3Y
2F3Z
2HF5
2I08
2JZI
2K0E
2K0F
2K0J
2K61
2KNE
2KUG
2KUH
2L53
2L7L
2LGF
2LL6
2LL7
2LQC
2LQP
2LV6
2M55
2R28
2V01
2V02
2VAY
2W73
2WEL
2X0G
2Y4V
3BYA
3DVE
3DVJ
3DVK
3DVM
3EWT
3EWV
3G43
3HR4
3J41
3O77
3O78
3OXQ
3SUI
3UCT
3UCW
3UCY
4DCK
4DJC
4GOW
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Response To Stimulus
Regulation Of Cellular Process
Cell Communication
Signaling
Cellular Response To Stimulus
Regulation Of Signaling
Signal Transduction
Response To Organic Substance
Positive Regulation Of Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cell Differentiation
Response To External Stimulus
Regulation Of Signal Transduction
Developmental Process
Regulation Of Catalytic Activity
Cellular Process
Response To Stress
Anatomical Structure Development
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Response To Organic Cyclic Compound
System Development
Regulation Of Ion Transport
Multicellular Organismal Development
Cellular Response To Organic Substance
Cell Surface Receptor Signaling Pathway
Cell-cell Signaling
Negative Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Establishment Of Localization In Cell
Positive Regulation Of Catalytic Activity
Negative Regulation Of Signaling
Cellular Localization
Synaptic Transmission
Regulation Of Cellular Protein Metabolic Process
Intracellular Signal Transduction
Regulation Of Phosphorylation
Locomotion
Regulation Of Cellular Localization
Positive Regulation Of Cellular Biosynthetic Process
Muscle System Process
Intracellular Transport
Regulation Of Ion Transmembrane Transport
Cytoplasmic Transport
Movement Of Cell Or Subcellular Component
Chemotaxis
Regulation Of Cellular Component Organization
Nervous System Development
Regulation Of Protein Kinase Activity
Generation Of Neurons
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
considering
dysregulated
endocrine
ep300
facilitates
geo
give
hope
hub
omnibus
partial
pls
posttraumatic
prkca
psychological
ptsd
recovered
representations
shed
signatures
square
squares
supports
theoretical
top
trauma
traumatic
underlie
variance
Tagcloud (Difference)
?
considering
dysregulated
endocrine
ep300
facilitates
geo
give
hope
hub
omnibus
partial
pls
posttraumatic
prkca
psychological
ptsd
recovered
representations
shed
signatures
square
squares
supports
theoretical
top
trauma
traumatic
underlie
variance
Tagcloud (Intersection)
?