ALG13 and PITX1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		ALG13	PITX1
Description		ALG13 UDP-N-acetylglucosaminyltransferase subunit	paired like homeodomain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane UDP-N-acetylglucosamine Transferase Complex Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Catalytic Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Hydrolase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Branchiomeric Skeletal Muscle Development Pituitary Gland Development Embryonic Hindlimb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Cartilage Development
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS
Drugs
Diseases			Congenital clubfoot; Congenital talipes equinovarus
GWAS		Rosacea symptom severity ( 29771307) Shoulder impingement or rotator cuff tear ( 33482370)	Appendicular lean mass ( 33097823) Atrial fibrillation ( 29237688) Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) DHEAS levels ( 34748635) Height ( 25429064 31562340 18391951 23563607 20881960) Hip circumference adjusted for BMI ( 34021172) Immune response to anthrax vaccine ( 22658931) Testicular germ cell tumor ( 28604732 23666240)
Interacting Genes		30 interacting genes: ATN1 ATXN1L BAG4 CPSF7 DMRTB1 EIF4ENIF1 ESRP1 EXOSC7 GRN HOXA1 KRT31 MAPKBP1 NXF2 PCM1 PITX1 PRRC2B QKI RBFOX1 RBFOX2 RBPMS RERE RHOU ROR2 RPL14 SF1 TRIM14 TXNL4A U2AF1 YTHDF3 ZC3H10	98 interacting genes: - ABHD11 ACTMAP AKAP8L ALG13 ANKRD10 ARID5A ATN1 BPIFA1 C10orf55 C1orf94 C9orf57 CDX4 CEACAM6 CFAP68 CYSRT1 DCTN3 DVL3 DZIP3 EFEMP2 EGR1 FAM168A FAM168B FOXO1 GATA1 GOLGA2 HGS HOXA1 HSF4 HYI IGFL2 IPO13 KLHL26 KRT34 KRT83 KRTAP13-1 KRTAP13-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LZTS2 MAGED1 METTL27 MGAT5B MSX2 MYH7B MYOZ3 NEUROD1 NHLRC4 NID2 NR5A1 PFDN5 PLA2G10 PLEKHB2 PLSCR1 PLSCR3 POU1F1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 PTK6 RBPMS RFX6 RHOXF2 RNF31 ROR2 SERGEF SERPINE1 SLC15A2 SMARCA2 SPAG8 STH TBX19 TBX22 TEKT5 TFAP2D TLE5 TP53BP1 TRAF1 TRAPPC2 TRIM23 TSC1 UFSP1 UPF2 VGLL3 YPEL3 ZBTB32 ZNF34
Entrez ID		79868	5307
HPRD ID		06542	03688
Ensembl ID		ENSG00000101901	ENSG00000069011
Uniprot IDs		A0A087WT15 A0A087WX43 Q9NP73	P78337 X5D9A5
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Binding RNA Processing Nucleic Acid Binding MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing RNA Metabolic Process Cytoplasmic Stress Granule U2AF Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Defense Response To Bacterium MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Nucleobase-containing Compound Metabolic Process P-body Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly Positive Regulation Of Aspartic-type Peptidase Activity Semicircular Canal Formation Internal N(7)-methylguanine-containing RNA Reader Activity Negative Regulation Of MRNA Modification Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MiRNA Binding Positive Regulation Of MRNA Metabolic Process RNA Transport Nucleobase-containing Compound Metabolic Process	Intermediate Filament Chromatin Protein Binding Keratin Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Lead Ion Binding Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mercury Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Transcription By RNA Polymerase II Axonemal A Tubule Inner Sheath Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Structural Molecule Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?