ALG13 and NXF2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ALG13	NXF2
Description		ALG13 UDP-N-acetylglucosaminyltransferase subunit	nuclear RNA export factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane UDP-N-acetylglucosamine Transferase Complex Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear RNA Export Factor Complex
	Molecular Function	Catalytic Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Hydrolase Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis	MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus RNA Transport MRNA Transport
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS	Transport of Mature mRNA derived from an Intron-Containing Transcript
Drugs
Diseases
GWAS		Rosacea symptom severity ( 29771307) Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		30 interacting genes: ATN1 ATXN1L BAG4 CPSF7 DMRTB1 EIF4ENIF1 ESRP1 EXOSC7 GRN HOXA1 KRT31 MAPKBP1 NXF2 PCM1 PITX1 PRRC2B QKI RBFOX1 RBFOX2 RBPMS RERE RHOU ROR2 RPL14 SF1 TRIM14 TXNL4A U2AF1 YTHDF3 ZC3H10	12 interacting genes: ALG13 APEX1 APP HNRNPUL1 MAP1A MAP1B NUP153 NUP214 NUP62 NXF1 NXT1 NXT2
Entrez ID		79868	56001
HPRD ID		06542	02260
Ensembl ID		ENSG00000101901	ENSG00000269405
Uniprot IDs		A0A087WT15 A0A087WX43 Q9NP73	Q9GZY0
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Binding RNA Processing Nucleic Acid Binding MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing RNA Metabolic Process Cytoplasmic Stress Granule U2AF Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Defense Response To Bacterium MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Nucleobase-containing Compound Metabolic Process P-body Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly Positive Regulation Of Aspartic-type Peptidase Activity Semicircular Canal Formation Internal N(7)-methylguanine-containing RNA Reader Activity Negative Regulation Of MRNA Modification Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MiRNA Binding Positive Regulation Of MRNA Metabolic Process RNA Transport Nucleobase-containing Compound Metabolic Process	RNA Export From Nucleus MRNA Transport Nuclear Export RNA Transport Nuclear Pore Nucleobase-containing Compound Transport Nuclear Pore Central Transport Channel Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear RNA Export Factor Complex Cellular Localization Establishment Of Localization In Cell MRNA Export From Nucleus Structural Constituent Of Nuclear Pore Poly(A)+ MRNA Export From Nucleus PTB Domain Binding Protein Transport Dendrite Development Establishment Of Protein Localization Nuclear Envelope Intracellular Protein Transport Nuclear Inclusion Body Neuron Projection Maintenance Intracellular Protein Localization Protein Import Into Nucleus Import Into Nucleus Nuclear Localization Sequence Binding Axonogenesis Amyloid Fibril Formation Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Protein Localization To Nucleus Protein Export From Nucleus Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule Depolymerization Microtubule Associated Complex Regulation Of Synaptic Plasticity Dendritic Shaft Neuron Projection Organization Microtubule-based Transport Positive Regulation Of Gene Expression, Epigenetic Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway
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