ALG13 and RPL14

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ALG13	RPL14
Description		ALG13 UDP-N-acetylglucosaminyltransferase subunit	ribosomal protein L14
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane UDP-N-acetylglucosamine Transferase Complex Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Ribosome Postsynaptic Density Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Catalytic Activity N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Hydrolase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis	Cytoplasmic Translation RRNA Processing Translation Ribosomal Large Subunit Biogenesis
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG14 causes ALG14-CMS	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Artenimol
Diseases
GWAS		Rosacea symptom severity ( 29771307) Shoulder impingement or rotator cuff tear ( 33482370)	Neuroticism ( 29255261)
Interacting Genes		30 interacting genes: ATN1 ATXN1L BAG4 CPSF7 DMRTB1 EIF4ENIF1 ESRP1 EXOSC7 GRN HOXA1 KRT31 MAPKBP1 NXF2 PCM1 PITX1 PRRC2B QKI RBFOX1 RBFOX2 RBPMS RERE RHOU ROR2 RPL14 SF1 TRIM14 TXNL4A U2AF1 YTHDF3 ZC3H10	8 interacting genes: ALG13 FBXO7 KCNK4 KLF10 PEX5 PHLDA1 PTEN TLE6
Entrez ID		79868	9045
HPRD ID		06542	10617
Ensembl ID		ENSG00000101901	ENSG00000188846
Uniprot IDs		A0A087WT15 A0A087WX43 Q9NP73	P50914
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Binding RNA Processing Nucleic Acid Binding MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process RNA Splicing RNA Metabolic Process Cytoplasmic Stress Granule U2AF Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleus Negative Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Defense Response To Bacterium MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Transcription Corepressor Activity Negative Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Nucleobase-containing Compound Metabolic Process P-body Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly Positive Regulation Of Aspartic-type Peptidase Activity Semicircular Canal Formation Internal N(7)-methylguanine-containing RNA Reader Activity Negative Regulation Of MRNA Modification Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MiRNA Binding Positive Regulation Of MRNA Metabolic Process RNA Transport Nucleobase-containing Compound Metabolic Process	Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Lewy Body Core Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Temperature-gated Cation Channel Activity Response To Arachidonate Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Arachidonate Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Response To Ultrasound Response To Alkaline PH Mechanosensitive Potassium Channel Activity Subcortical Maternal Complex Cytoplasmic Lattice Protein Storage Structural Constituent Of Cytoplasmic Lattice UDP-N-acetylglucosamine Transferase Complex N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Circadian Rhythm Lipid Modification Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Myelin Sheath Adaxonal Region Regulation Of Developmental Process Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Multicellular Organismal Development Regulation Of Synaptic Vesicle Clustering Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Cycle G1/S Phase Transition Postsynaptic Density Assembly
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