MB21D2 and SLC12A4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MB21D2	SLC12A4
Description		Mab-21 domain containing 2	solute carrier family 12 member 4
Image
GO Annotations	Cellular Component		Lysosomal Membrane Plasma Membrane Membrane Synapse
	Molecular Function	Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein-containing Complex Binding Cadherin Binding	Protein Binding ATP Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Protein Serine/threonine Kinase Binding
	Biological Process		Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters
Drugs			Potassium chloride Bumetanide
Diseases
GWAS		Anti-saccade response ( 29064472)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		13 interacting genes: ARHGEF5 ATXN7L2 BYSL CBX8 CIRSR DTNB EVI5 MORN3 RAB3IP REL SLC12A4 SPRY1 SPRY2	10 interacting genes: AP3M1 ATF7IP CNFN CYSRT1 KRTAP12-2 KRTAP19-2 MB21D2 MTNR1B TMEM102 ZNF655
Entrez ID		151963	6560
HPRD ID		14092	04987
Ensembl ID		ENSG00000180611	ENSG00000124067
Uniprot IDs		Q8IYB1	B4DF30 Q9UP95
PDB IDs		7LT1	6KKR 6KKT 6KKU 7AIP 7AIQ 7AIR 7TTH 7TTI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Axis Elongation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Ras Protein Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Import Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Lung Growth Ciliary Basal Body-plasma Membrane Docking Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development
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