MB21D2 and RAB3IP

Number of citations of the paper that reports this interaction (PubMedID 27173435)
70

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MB21D2	RAB3IP
Description		Mab-21 domain containing 2	RAB3A interacting protein
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GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Lamellipodium Vesicle Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Proximal Dendrite
	Molecular Function	Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein-containing Complex Binding Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding GTPase Binding
	Biological Process		Protein Targeting To Membrane Golgi To Plasma Membrane Transport Protein Transport Negative Regulation Of Filopodium Assembly Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways			Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium BBSome-mediated cargo-targeting to cilium RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472)	Diastolic blood pressure ( 27841878) Height ( 28552196) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		13 interacting genes: ARHGEF5 ATXN7L2 BYSL CBX8 CIRSR DTNB EVI5 MORN3 RAB3IP REL SLC12A4 SPRY1 SPRY2	32 interacting genes: BANP CCDC196 CHCHD3 DNAJB13 FAM124A KRT40 MB21D2 MBD3 MVP NAA10 PEG10 PKN1 PLOD3 PPL PRKAB2 RAB11A RAB3A RAB3D RAB3IL1 RAB8A RAB8B RUFY1 SFN SSX2 SUV39H2 TBC1D21 TEPSIN TRAPPC6A TXNDC5 ZBTB16 ZNF410 ZNF76
Entrez ID		151963	117177
HPRD ID		14092	10565
Ensembl ID		ENSG00000180611	ENSG00000127328
Uniprot IDs		Q8IYB1	Q96QF0
PDB IDs		7LT1	4LHX 4LHY 4LHZ 4UJ3 4UJ4 4UJ5 6F6P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Bud Elongation Involved In Lung Branching Regulation Of Lens Fiber Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Branch Elongation Of An Epithelium Axis Elongation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Ras Protein Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Establishment Of Spindle Localization ERK1 And ERK2 Cascade Spindle Localization Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Import Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Lung Growth Ciliary Basal Body-plasma Membrane Docking Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development	Myosin V Binding Protein Transport Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Exocytosis Plasma Membrane To Endosome Transport Intracellular Protein Localization Vesicle Organization GTPase Activity Vesicle-mediated Transport Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Endocytic Recycling Trans-Golgi Network Transport Vesicle Endosome Establishment Of Protein Localization Phagocytic Vesicle GTP Binding Vesicle-mediated Transport In Synapse GTP-dependent Protein Binding Secretion By Cell Cytoplasmic Vesicle Recycling Endosome Membrane Extracellular Exosome Regulation Of Long-term Neuronal Synaptic Plasticity Trans-Golgi Network Membrane Organelle Organization Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Endosomal Transport Regulation Of Presynaptic Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Synaptic Vesicle Endosomal Processing Coated Vesicle Membrane Organelle Fusion
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