TFPI2 and PLG

Number of citations of the paper that reports this interaction (PMID 8555184)
20

Data Source:
HPRD (in vitro)

		TFPI2	PLG
Gene Name		tissue factor pathway inhibitor 2	plasminogen
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Nucleus	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding
	Biological Process	Blood Coagulation Negative Regulation Of Endopeptidase Activity	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS			Aging ( 22773346) Lp (a) levels ( 21900290)
Protein-Protein Interactions		5 interactors: F11 KLKB1 PLG SKIL SMURF2	61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		7980	5340
HPRD ID		08962	01417
Ensembl ID		ENSG00000105825	ENSG00000122194
Uniprot IDs		P48307 Q8NAK6	P00747 Q5TEH5
PDB IDs		1ZR0	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Fibrinolysis Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Fibrinolysis Blood Coagulation Hemostasis Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Zymogen Activation Response To Wounding Transforming Growth Factor Beta Receptor Signaling Pathway Factor XII Activation Protein Activation Cascade Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Mononuclear Cell Migration Response To Transforming Growth Factor Beta Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin DNA-templated Transcription, Initiation Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Kallikrein-kinin Cascade Negative Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Protein Heterotrimerization Protein Homotrimerization Trophoblast Giant Cell Differentiation Positive Regulation Of Protein Processing Muscle Structure Development In Utero Embryonic Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process	Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity
Tagcloud ?		anticipated aplp2 appi bikunin canonical cleavage cleave cleaved cocrystal conformation displaying hai2 hepatocyte kunitz mesotrypsin offers p1 polypeptide possessing preferences protease proteolytic selectin stabilization stabilized substrates tfpi1 trypsin uniquely	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Difference) ?		anticipated aplp2 appi bikunin canonical cleavage cleave cleaved cocrystal conformation displaying hai2 hepatocyte kunitz mesotrypsin offers p1 polypeptide possessing preferences protease proteolytic selectin stabilization stabilized substrates tfpi1 trypsin uniquely	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Intersection) ?