TFPI2 and ZAN

Data Source: HiPPIP (Novel)

		TFPI2	ZAN
Name		tissue factor pathway inhibitor 2	zonadhesin
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Space Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Peptidase Inhibitor Activity	Extracellular Matrix Structural Constituent
	Biological Process	Blood Coagulation Hemostasis	Cell Adhesion Binding Of Sperm To Zona Pellucida Cell-cell Adhesion
Pathways		Developmental Lineage of Pancreatic Ductal Cells	None
GWAS		Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 )	Bipolar disorder ( 31043756 ) Heel bone mineral density ( 30598549 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 ) White matter hyperintensities ( 32358547 )
Novel Interactors		1 novel interactors: ZAN	2 novel interactors: RASA4 TFPI2
Interacting Genes		5 interacting genes: F11 KLKB1 PLG SKIL SMURF2	None recorded
Entrez ID		7980	7455
HPRD ID		08962	03846
Ensembl ID		ENSG00000105825	ENSG00000146839
Uniprot IDs		P48307	B4DYT6 Q9Y493
PDB IDs		1ZR0	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Fibrinolysis Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Coagulation Blood Coagulation Hemostasis Plasminogen Activation Serine-type Peptidase Activity Regulation Of Wound Healing Serine-type Endopeptidase Activity Fibrinolysis Regulation Of Response To Wounding Protein Processing Zymogen Activation Regulation Of Body Fluid Levels Protein Maturation SMAD Binding Negative Regulation Of BMP Signaling Pathway Proteolysis Peptidase Activity Serine-type Aminopeptidase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Extracellular Space Factor XII Activation Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Trans-synaptic Signaling By BDNF Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Protein Domain Specific Binding Protein Antigen Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Trophoblast Giant Cell Differentiation Lens Fiber Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane	None