PDLIM4 and AMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDLIM4	AMT
Description		PDZ and LIM domain 4	aminomethyltransferase
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GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Actin Cytoskeleton Membrane Z Disc Lamellipodium Early Endosome Membrane Early Endosome Lumen Filamentous Actin Recycling Endosome Lumen Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Nucleoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Muscle Alpha-actinin Binding Alpha-actinin Binding	Aminomethyltransferase Activity Protein Binding Transaminase Activity Transferase Activity
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development Excitatory Chemical Synaptic Transmission	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System
Pathways			Glycine degradation
Drugs			Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Height ( 28552196) Inflammatory bowel disease ( 23128233 28067908) Mosquito bite size ( 28199695) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		8 interacting genes: ABCA1 AMT FAM222B PTPN13 RBPMS SDCBP TRIP6 ZNF408	2 interacting genes: PDLIM4 VAC14
Entrez ID		8572	275
HPRD ID		04571	01997
Ensembl ID		ENSG00000131435	ENSG00000145020
Uniprot IDs		A0A0S2Z4N4 P50479	P48728
PDB IDs		2EEG 2V1W 4Q2O	1WSR 1WSV
Enriched GO Terms of Interacting Partners?
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