PDLIM4 and PTPN13

Number of citations of the paper that reports this interaction (PMID 11884147)
14

Data Source:
HPRD (in vitro, two hybrid)

		PDLIM4	PTPN13
Gene Name		PDZ and LIM domain 4	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Image
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process		Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: ABCA1 PTPN13 RBPMS TRIP6 ZNF408	21 interactors: APC ARHGAP29 BRD7 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR NFKBIA NGFR NGFRAP1 PDLIM4 PKN2 PLEKHA1 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		8572	5783
HPRD ID		04571	02602
Ensembl ID		ENSG00000131435	ENSG00000163629
Uniprot IDs		P50479	Q12923
PDB IDs		2EEG 2V1W	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Interleukin-1 Beta Secretion Regulation Of Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Intracellular Transport Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Regulation Of Intracellular Protein Transport Regulation Of Signaling Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Protein Transport Platelet Dense Granule Organization Cellular Macromolecule Biosynthetic Process Phospholipid Efflux Phagocytosis, Engulfment Macromolecule Biosynthetic Process Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Intracellular Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination Reverse Cholesterol Transport Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Regulation Of Protein Transport	Signal Transduction Signaling Cell Communication Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Proliferation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Necroptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Cell Adhesion T Cell Differentiation In Thymus Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Death Cell-cell Junction Organization Motor Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of Myeloid Leukocyte Differentiation Necroptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Difference) ?		adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Intersection) ?