USP22 and HEXA

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid)

		USP22	HEXA
Name		ubiquitin specific peptidase 22	hexosaminidase subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex	Lysosome Cytosol Membrane Azurophil Granule Lysosomal Lumen Extracellular Exosome Beta-N-acetylhexosaminidase Complex
	Molecular Function	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-N-acetylhexosaminidase Activity Protein Binding Acetylglucosaminyltransferase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Heterodimerization Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle	Skeletal System Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process N-glycan Processing Lipid Metabolic Process Ganglioside Catabolic Process Lysosome Organization Sensory Perception Of Sound Locomotory Behavior Adult Walking Behavior Lipid Storage Sexual Reproduction Glycosaminoglycan Metabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process Myelination Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Carbohydrate Derivative Metabolic Process
Pathways		HATs acetylate histones Ub-specific processing proteases	Keratan sulfate degradation CS/DS degradation Hyaluronan degradation Defective HEXA causes GM2G1 (Hyaluronan metabolism) Glycosphingolipid catabolism
Diseases		None	GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Body mass index ( 26426971 ) Mosquito bite size ( 28199695 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: B9D1	None recorded
Interacting Genes		17 interacting genes: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1	3 interacting genes: CREBBP GM2A USP22
Entrez ID		23326	3073
HPRD ID		19411	06040
Ensembl ID		ENSG00000124422	ENSG00000213614
Uniprot IDs		Q9UPT9	A0A0S2Z3W3 B4DVA7 H3BP20 P06865
PDB IDs		Not available	2GJX 2GK1
GO Terms Enriched among Interactors		Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome	Protein Deubiquitination Protein Modification By Small Protein Removal Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Regulation Of DNA Repair Peptide Lactyltransferase (CoA-dependent) Activity Beta-N-acetylhexosaminidase Activity Histone H2B Deubiquitinase Activity MRF Binding Transcription Coactivator Activity Histone H2A Deubiquitinase Activity Ganglioside Catabolic Process Negative Regulation Of Transcription By RNA Polymerase I N-terminal Protein Amino Acid Acetylation Phospholipase Activator Activity Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Regulation Of DNA Metabolic Process Acetyltransferase Activity Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Oligosaccharide Catabolic Process Transcription Factor TFTC Complex Histone Acetyltransferase Complex Chromatin Remodeling Protein-lysine-acetyltransferase Activity Ganglioside Metabolic Process Lipid Transporter Activity SAGA Complex Protein K48-linked Deubiquitination Protein Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Lipid Storage Post-translational Protein Modification Chromatin Organization Sphingolipid Catabolic Process Regulation Of Transcription By RNA Polymerase I Tau Protein Binding Membrane Lipid Catabolic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Neuromuscular Process Controlling Balance