USP22 and HEXA

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)

		USP22	HEXA
Gene Name		ubiquitin specific peptidase 22	hexosaminidase A (alpha polypeptide)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	SAGA Complex SAGA-type Complex	Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	Beta-N-acetylhexosaminidase Activity Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Transcription, DNA-templated Cell Cycle Embryo Development Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process	Carbohydrate Metabolic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Metabolism of lipids and lipoproteins Defective B4GALT7 causes EDS, progeroid type Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Sphingolipid metabolism Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Glycosphingolipid metabolism Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AASDHPPT HEXA HIST2H2AC HIST2H2BE MRPL10 MRPL44 PSME1 SCFD1 UBC	2 interactors: GM2A USP22
Entrez ID		23326	3073
HPRD ID		19411	06040
Ensembl ID		ENSG00000124422	ENSG00000213614
Uniprot IDs		Q9UPT9	H3BP20 P06865
PDB IDs			1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Translation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Signal Transduction By P53 Class Mediator Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Protein Polyubiquitination Translational Elongation Cellular Protein Complex Disassembly	Ganglioside Catabolic Process Oligosaccharide Catabolic Process Ganglioside Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Histone Deubiquitination Ceramide Catabolic Process Sphingolipid Catabolic Process Membrane Lipid Catabolic Process Histone Ubiquitination Lipid Storage Oligosaccharide Metabolic Process Histone H4 Acetylation
Tagcloud ?		activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft	alanine associate carboxy catalysis derivatized eluted glu70 heterodimeric histidine hxxehx76h inserted inserting lys215 mpp mutagenesis nickel peptidase plasmon polypeptide positions presequences proper residue resin ser114 ser314 stochiometry surrounding tagged
Tagcloud (Difference) ?		activates additionally along arrests clinicopathologic curbs downregulates g0 g1 great immunoprecipitation inhibits interacts mdmx nsclc oncology overexpressed phases promotes protease represent reverses shows shrna silencing tumorigenesis ubiquitin upregulation xenograft	alanine associate carboxy catalysis derivatized eluted glu70 heterodimeric histidine hxxehx76h inserted inserting lys215 mpp mutagenesis nickel peptidase plasmon polypeptide positions presequences proper residue resin ser114 ser314 stochiometry surrounding tagged
Tagcloud (Intersection) ?