PDS5B

Description		PDS5 cohesin associated factor B
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Protein Binding Cohesin Unloader Activity
	Biological Process	Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		7 interacting genes: APP BRCA2 CEBPA CFTR HASPIN PALB2 RAD51
Entrez ID		23047
HPRD ID		05624
Ensembl ID		ENSG00000083642
Uniprot IDs		Q9NTI5
PDB IDs		5HDT
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Mitotic Recombination-dependent Replication Fork Processing Cell Maturation Developmental Maturation Nuclear Ubiquitin Ligase Complex Lateral Element Telomere Maintenance Via Recombination DNA Repair Complex Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Inner Cell Mass Cell Proliferation Recombinational Repair Mitotic Recombination Regulation Of DNA Damage Checkpoint Hematopoietic Stem Cell Proliferation Response To X-ray Double-strand Break Repair DNA Recombination Replication Fork Processing Meiosis I Cellular Response To Stress Response To Gamma Radiation Response To Stress Cellular Response To CAMP Chromosome Organization Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Meiosis I Cell Cycle Process Meiotic Nuclear Division BRCA2-MAGE-D1 Complex Cellular Response To Ionizing Radiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Glucoside Stem Cell Proliferation DNA Binding Response To Radiation Response To CAMP Nuclear Division Regulation Of Cell Cycle Phase Transition Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Chromatin Binding
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