PDS5B and HASPIN

Number of citations of the paper that reports this interaction (PubMedID 28343969)
0

Data Source:
BioGRID (two hybrid)

		PDS5B	HASPIN
Description		PDS5 cohesin associated factor B	histone H3 associated protein kinase
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytoskeleton
	Molecular Function	DNA Binding Protein Binding Cohesin Unloader Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone H3T3 Kinase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division	Mitotic Cell Cycle Chromatin Organization Chromatin Remodeling Protein Phosphorylation Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Chromosome Organization Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs			5-iodotubercidin 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine H-89 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Parkinson's disease ( 34064523)
Interacting Genes		7 interacting genes: APP BRCA2 CEBPA CFTR HASPIN PALB2 RAD51	6 interacting genes: AURKB CDK1 H3C1 HSF2BP MDFI PDS5B
Entrez ID		23047	83903
HPRD ID		05624	17083
Ensembl ID		ENSG00000083642	ENSG00000177602
Uniprot IDs		Q9NTI5	A0PJ70 Q8TF76
PDB IDs		5HDT	2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E 7AVQ 7OPS 7SQM 8RDK 9B2S 9B2T 9B2U 9FLB 9FLC 9FLO 9FLQ 9FLR 9FLT
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Mitotic Recombination-dependent Replication Fork Processing Cell Maturation Developmental Maturation Nuclear Ubiquitin Ligase Complex Lateral Element Telomere Maintenance Via Recombination DNA Repair Complex Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Inner Cell Mass Cell Proliferation Recombinational Repair Mitotic Recombination Regulation Of DNA Damage Checkpoint Hematopoietic Stem Cell Proliferation Response To X-ray Double-strand Break Repair DNA Recombination Replication Fork Processing Meiosis I Cellular Response To Stress Response To Gamma Radiation Response To Stress Cellular Response To CAMP Chromosome Organization Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Meiosis I Cell Cycle Process Meiotic Nuclear Division BRCA2-MAGE-D1 Complex Cellular Response To Ionizing Radiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Glucoside Stem Cell Proliferation DNA Binding Response To Radiation Response To CAMP Nuclear Division Regulation Of Cell Cycle Phase Transition Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Chromatin Binding	Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Chromosome Segregation Chromosome Protein Localization To Chromosome, Centromeric Region Spindle Microtubule Cell Cycle G2/M Phase Transition Chromosome Organization Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Nucleoplasm Protein Localization To Chromosome Mitotic DNA-templated DNA Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cyclin B1-CDK1 Complex Positive Regulation Of Chromosome Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cell Division Mitotic Sister Chromatid Biorientation Repair Of Mitotic Kinetochore Microtubule Attachment Defect Cohesin Unloader Activity Regulation Of Cell Cycle G2/M Phase Transition Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation Cyclin-dependent Protein Kinase Activity Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Mitotic Cytokinesis Checkpoint Signaling Sister Chromatid Biorientation Cell Cycle Phase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Thymidine Biosynthetic Process Positive Regulation Of Microtubule Depolymerization Golgi Disassembly Nuclear DNA Replication Midbody Histone Kinase Activity Chromosome Passenger Complex Thymidine Metabolic Process
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