CST6 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		CST6	PALB2
Description		cystatin E/M	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	DNA Binding Protein Binding
	Biological Process	Epidermis Development Anatomical Structure Morphogenesis	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs
Diseases			Fanconi anemia
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 17554300)
Interacting Genes		7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		1474	79728
HPRD ID		03535	07966
Ensembl ID		ENSG00000175315	ENSG00000083093
Uniprot IDs		Q15828	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs		4N6L 4N6M 4N6N 4N6O 6FK0	2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway NF-kappaB Binding Myeloid Dendritic Cell Activation Gland Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Microtubule Anchoring At Centrosome Regulation Of Intracellular Signal Transduction Enzyme Binding Developmental Growth Regulation Of MiRNA Transcription Dendritic Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Kidney Epithelium Development Positive Regulation Of Myeloid Leukocyte Differentiation Heart Valve Morphogenesis Positive Regulation Of Muscle Cell Differentiation Response To Xenobiotic Stimulus Response To Glucoside Cellular Response To Ionizing Radiation Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Glycogen (starch) Synthase Activity Epithelial To Mesenchymal Transition Positive Regulation Of Intracellular Protein Transport Mesenchymal Cell Differentiation Insulin Receptor Signaling Pathway Tissue Remodeling Cholangiocyte Proliferation Multicellular Organism Growth Regulation Of MiRNA Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Intrahepatic Bile Duct Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Liver Development Liver Morphogenesis Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Positive Regulation Of Primary MiRNA Processing	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I
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