CST6

Description		cystatin E/M
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Epidermis Development Anatomical Structure Morphogenesis
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A
Entrez ID		1474
HPRD ID		03535
Ensembl ID		ENSG00000175315
Uniprot IDs		Q15828
PDB IDs		4N6L 4N6M 4N6N 4N6O 6FK0
Enriched GO Terms of Interacting Partners?		Enzyme-linked Receptor Protein Signaling Pathway NF-kappaB Binding Myeloid Dendritic Cell Activation Gland Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Microtubule Anchoring At Centrosome Regulation Of Intracellular Signal Transduction Enzyme Binding Developmental Growth Regulation Of MiRNA Transcription Dendritic Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Kidney Epithelium Development Positive Regulation Of Myeloid Leukocyte Differentiation Heart Valve Morphogenesis Positive Regulation Of Muscle Cell Differentiation Response To Xenobiotic Stimulus Response To Glucoside Cellular Response To Ionizing Radiation Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Glycogen (starch) Synthase Activity Epithelial To Mesenchymal Transition Positive Regulation Of Intracellular Protein Transport Mesenchymal Cell Differentiation Insulin Receptor Signaling Pathway Tissue Remodeling Cholangiocyte Proliferation Multicellular Organism Growth Regulation Of MiRNA Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Intrahepatic Bile Duct Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Liver Development Liver Morphogenesis Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Positive Regulation Of Primary MiRNA Processing
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