ZMAT4 and LRSAM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZMAT4	LRSAM1
Description		zinc finger matrin-type 4	leucine rich repeat and sterile alpha motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Brain volume in infants (grey matter) ( 28763065) Coffee consumption ( 31046077) Fasting plasma glucose ( 17903298) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Hip circumference ( 28552196) Iris color (L* coordinate) ( 30895295) Lung cancer ( 28604730) Myopia ( 27182965) Pediatric areal bone mineral density (concordant skeletal phenotype) ( 29240982) Refractive error ( 23396134 32231278) Severe aplastic anemia ( 32004448) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference ( 28552196)	Mean corpuscular volume ( 32888494)
Interacting Genes		9 interacting genes: ADARB1 APP CUL3 CUL4B DAPK1 LRSAM1 SRPK2 STRBP TARBP2	46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4
Entrez ID		79698	90678
HPRD ID		07837	14325
Ensembl ID		ENSG00000165061	ENSG00000148356
Uniprot IDs		Q9H898	A0A6Q8PGW1 Q6UWE0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Double-stranded RNA Binding Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Regulation Of Viral Life Cycle Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Viral Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Modification Process Regulation Of Mitotic Cell Cycle Identical Protein Binding Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Metabolic Process Defense Response Hypoglossal Nerve Morphogenesis Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of SiRNA Processing Protein Modification By Small Protein Conjugation Positive Regulation Of Neuron Apoptotic Process Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Post-translational Protein Modification Developmental Growth Regulation Of Primary Metabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Trophectodermal Cellular Morphogenesis Liver Morphogenesis Apoptotic Process Negative Regulation Of Protein Phosphorylation	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process
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