ZMAT4 and THAP1

		ZMAT4	THAP1
Description		zinc finger matrin-type 4	THAP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Body fat mass ( 28552196) Brain volume in infants (grey matter) ( 28763065) Coffee consumption ( 31046077) Fasting plasma glucose ( 17903298) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Hip circumference ( 28552196) Iris color (L* coordinate) ( 30895295) Lung cancer ( 28604730) Myopia ( 27182965) Pediatric areal bone mineral density (concordant skeletal phenotype) ( 29240982) Refractive error ( 23396134 32231278) Severe aplastic anemia ( 32004448) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference ( 28552196)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		9 interacting genes: ADARB1 APP CUL3 CUL4B DAPK1 LRSAM1 SRPK2 STRBP TARBP2	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		79698	55145
HPRD ID		07837	15496
Ensembl ID		ENSG00000165061	ENSG00000131931
Uniprot IDs		Q9H898	Q9NVV9
PDB IDs			2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Double-stranded RNA Binding Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Regulation Of Viral Life Cycle Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Viral Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Modification Process Regulation Of Mitotic Cell Cycle Identical Protein Binding Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Metabolic Process Defense Response Hypoglossal Nerve Morphogenesis Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of SiRNA Processing Protein Modification By Small Protein Conjugation Positive Regulation Of Neuron Apoptotic Process Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Post-translational Protein Modification Developmental Growth Regulation Of Primary Metabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Trophectodermal Cellular Morphogenesis Liver Morphogenesis Apoptotic Process Negative Regulation Of Protein Phosphorylation	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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