HMBOX1 and AEBP2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HMBOX1	AEBP2
Gene Name		homeobox containing 1	AE binding protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661) Pulmonary function ( 21946350)
Protein-Protein Interactions		48 interactors: AEBP2 APP ASB7 ATP5O BYSL C20orf195 C8orf33 CARD9 CBX8 CCNG1 DAB1 DYNLL2 ENTPD2 FAM13C FAM161A FAM206A FAM74A4 FARS2 FRMD6 FXR2 KAT5 LNX1 MAGEH1 MFAP1 MORF4L1 MRPL11 MRPL28 PIP4K2B PKD1P1 PRKAA1 PRKAA2 RBMY2FP REEP6 RPL9 SAP30L SFR1 SH2D4A SNRPB2 TCEANC UBA6 UBE2Z VPS72 ZBTB24 ZMAT2 ZNF337 ZNF417 ZNF581 ZNF587	10 interactors: APP EED HIST1H1A HIST1H1C HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12
Entrez ID		79618	121536
HPRD ID		07964	16477
Ensembl ID		ENSG00000147421
Uniprot IDs		D3DSU2 Q6NT76	Q6ZN18
PDB IDs		2CUF 4J19
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Chromatin Organization Biosynthetic Process Chromatin Modification Cellular Metabolic Process Regulation Of Energy Homeostasis Positive Regulation Of Glycolytic Process Chromosome Organization Fatty Acid Homeostasis Histone Modification Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Cholesterol Metabolic Process Organelle Organization Sterol Metabolic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Translational Termination Positive Regulation Of Autophagy Neuron Recognition Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Synaptic Target Recognition Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Double-strand Break Repair Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Histone Phosphorylation Sterol Biosynthetic Process Protein Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Anion Homeostasis Translational Elongation Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Cellular Process Regulation Of RNA Metabolic Process Cerebellum Structural Organization	Chromatin Organization Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Chromatin Modification Regulation Of Gene Expression, Epigenetic DNA Conformation Change Organelle Organization Histone Modification RNA Metabolic Process Histone H3-R2 Demethylation Histone H4-R3 Demethylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Gene Expression Synaptic Growth At Neuromuscular Junction Transcription, DNA-templated RNA Biosynthetic Process Histone Methylation Negative Regulation Of Gene Expression Cell Recognition Collateral Sprouting In Absence Of Injury Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Protein Methylation Regulation Of RNA Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Nucleobase-containing Compound Metabolic Process Nucleosome Positioning Axon Choice Point Recognition Recognition Of Apoptotic Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuron Remodeling DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone H3-K27 Methylation Regulation Of Histone H3-K27 Methylation Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		adherens aqp2 aqp3 bioinformatic collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 scnn1b scnn1g vasopressin	chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides repression step trimethylation
Tagcloud (Difference) ?		adherens aqp2 aqp3 bioinformatic collecting crebbp ctnnb1 duct elf3 enacbeta enacgamma esbl flanking gatad2b gov helixweb http hypotheses isotope junb junctions mnpd mpkccd nih pser552 rangap1 scnn1b scnn1g vasopressin	chromatin complexes components constitute creates domains establishing feedback form h2a h2aub h3k27 h3k27me3 histone jarid2 k27 key loop monoubiquitination nucleosomes pcr2 polycomb prc1 prc2 promotes provides repression step trimethylation
Tagcloud (Intersection) ?