HMBOX1 and SDCBP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HMBOX1	SDCBP
Description		homeobox containing 1	syndecan binding protein
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Anchoring Junction Blood Microparticle Extracellular Vesicle
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Anchor Activity Lipid Binding Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein Sequestering Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Telomerase Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Telomere-telomerase Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Ras Protein Signal Transduction Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of JNK Cascade Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways			Ephrin signaling Neurofascin interactions RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Neutrophil degranulation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Aspartate aminotransferase levels ( 33547301) Fasting insulin ( 34074324) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		98 interacting genes: ABITRAM AEBP2 ANKRD36 APP ATP5PO BAZ2B BEND7 BRD1 BYSL C8orf33 CARD9 CBX8 CCDC187 CCNG1 CDC7 CDCA8 CDK18 DAB1 DNTTIP1 DYNLL1 ENKD1 ENTPD2 FAM13C FAM161A FAM217B FAM74A4 FAM90A1 FARS2 FGF11 FNDC11 FRMD6 FXR2 GAS2L2 GNL3L GSC2 INO80B IPO13 KAT5 KIF9 LMO1 LMO3 LNX1 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MORF4L1 MORF4L2 MRPL11 MRPL28 PAX5 PAX6 PIAS2 PICK1 PIP4K2B PKD1P1 POLDIP3 POLL PRKAA1 PRKAA2 PRPF18 RBMY2FP RCOR3 REEP6 RPL9 RPS25 SAP30L SCNM1 SDCBP SFR1 SH2D4A SNRPB2 SNW1 SYT6 TBP TCEA2 TCEANC TSGA10IP TUFM U2AF2 UBA6 UBE2I UBE2Z VAX1 VPS72 WT1 ZBTB24 ZBTB26 ZFYVE26 ZMAT2 ZMYM5 ZNF250 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688	308 interacting genes: - ABI2 AIRIM ANKRD33 ANKRD36B ANKRD40 ANP32B APIP ARFIP2 ARL6IP1 BCL2L15 BEND7 C11orf68 C1orf35 C2CD2L CABP5 CADM1 CADPS CALCOCO2 CALM1 CALM2 CALM3 CAV2 CBR3 CBY2 CCDC102B CCDC106 CD6 CD63 CDA CDC34 CDCP1 CDIPT CDKN2D CEP55 CEP85 CGGBP1 CHIC2 CHMP1A CLK2 CLK3 CMTM5 COX4I1 CRX CRYAA CT45A1 CT45A10 CT45A3 CT45A5 CTBP2 CTDSP1 CUTC DCTD DCTPP1 DDX39B DERL3 DMC1 DNM2 DRAP1 DTNBP1 DYNLT1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A EIF5A2 ELAVL1 EMILIN3 ENOX1 ENTR1 EPHB2 ERICH2 EXOSC4 FADD FAM118A FAM118B FAM9A FAM9B FHL3 FHL5 FLAD1 FOXP2 FTH1 FTL GET4 GGPS1 GKAP1 GNMT GOLT1B GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 GRXCR1 GSC2 GSG1 HEXIM2 HHAT HIVEP1 HMBOX1 HMGB3 HNRNPC HOMER3 HOMEZ HOXA1 HOXA7 HPRT1 HSBP1 HSF2BP HUS1 ID3 IGFBP6 IHO1 IKZF1 IL5RA INO80E KATNBL1 KCNH1 KCNJ2 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRT14 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP5-9 LCOR LDB2 LDHB LDOC1 LEPROTL1 LGALS2 LSM6 LURAP1L LZTFL1 MAD2L1 MAPK9 MAPRE3 MATN4 MBD3 MED4 MEOX1 MEOX2 MGLL MID2 MINDY3 MKRN1 MOBP MRFAP1 MRFAP1L1 MTUS2 MYBPC2 MYLIP N4BP3 NADK NAGK NAPB NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OCM ODAM OPTN OSTF1 PCBD1 PCYT1A PDCD6IP PDE4DIP PDE9A PDLIM4 PDZK1IP1 PFDN5 PHC2 PHF11 PIH1D2 PNMA1 PNMA2 POLR2J POLR3K PPARA PRPF38A PRPF40A PRR13 PSMB3 PSMC6 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RALY RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9 RP9P RPIA RPL22 RPRD1A RPRM RPS26 RRM2 RRS1 RTL8B RTN1 RUNDC3A S100B SCG3 SCML1 SDC1 SDC2 SDC4 SDCBP2 SEPTIN1 SEPTIN3 SET SFT2D1 SIAH1 SLC50A1 SLC6A5 SMARCA2 SNRPA SNX1 SOX4 SPANXN3 SREK1IP1 SRSF11 SRSF3 SRSF7 SSC5D SSNA1 STX1A SUB1 SULT1B1 SYNGR1 SYPL1 SYS1 TCF21 TCF4 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMCO2 TMEM17 TMEM239 TNFAIP8 TNFAIP8L3 TNKS TRAF5 TRARG1 TRIM27 TRIM32 TRIM38 TRIM54 TRIP13 TSN UBB UBC UBE2A UBE2K UBE2R2 ULK1 WASHC1 WASHC3 WASL WDR91 YAP1 YIF1A ZBTB14 ZBTB8A ZCCHC10 ZCCHC17 ZFTRAF1 ZMYND12 ZNF343 ZNF485 ZNF660 ZNF768 ZRANB1 ZSCAN23
Entrez ID		79618	6386
HPRD ID		07964	03741
Ensembl ID		ENSG00000147421	ENSG00000137575
Uniprot IDs		Q6NT76	B4DHN5 G5EA09 O00560
PDB IDs		2CUF 4J19	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33 6R9H 6RLC 7FSG 7FSH 7FSI 7FSJ 7FSK 7FSL 7FSM 7FSN 7FSO 7FSP 7FSQ 7FSR 7FSS 7FST 7FSU 7FSV 7FSW 7FSX 7FSY 7FSZ 7FT0 7FT1 7FT2 7FT3 7FT4 7FT5 7FT6 7FT7 7FT8 7FT9 7FTA 7FTB 7FTC 7FTD 8AAI 8AAK 8AAO 8AAP 8BLU 8BLV 8HCK
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Speck Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Lipid Droplet Disassembly Protein Binding Positive Regulation Of DNA Repair NuA4 Histone Acetyltransferase Complex Regulation Of Macromolecule Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Recombination Chromatin Organization Spliceosomal Complex Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Glucose Starvation Protein Localization To Lipid Droplet Positive Regulation Of DNA Metabolic Process Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Somite Specification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Repair Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Phosphatidylethanolamine Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Regulation Of Tubulin Deacetylation Astrocyte Differentiation	Identical Protein Binding Protein Binding Glutamate-gated Receptor Activity Glutamate Receptor Signaling Pathway AMPA Glutamate Receptor Activity Nucleus Glutamate-gated Calcium Ion Channel Activity Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Cytosol Postsynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Extracellular Exosome Assembly Regulation Of Actin Nucleation Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Positive Regulation Of Synaptic Transmission Endocytic Vesicle Membrane Protein Homooligomerization Protein Complex Oligomerization Asymmetric Synapse Protein Tetramerization Glutamate Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Nucleoplasm Dendritic Spine Ligand-gated Ion Channel Signaling Pathway Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Modulation Of Chemical Synaptic Transmission Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Extracellular Exosome Assembly Postsynaptic Density Membrane Protein Homotetramerization Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Glutamate Receptor Signaling Pathway Presynaptic Membrane Ferric Iron Binding Phosphatidylinositol 3-kinase Inhibitor Activity Female Meiosis I Calcium Channel Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Membrane Tubulation Ferritin Complex Group II Metabotropic Glutamate Receptor Activity Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Long-term Synaptic Potentiation
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