CARS2 and GABARAP

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		CARS2	GABARAP
Description		cysteinyl-tRNA synthetase 2, mitochondrial	GABA type A receptor-associated protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Golgi Membrane Autophagosome Membrane Cytoplasm Lysosome Autophagosome Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Endomembrane System Actin Cytoskeleton Membrane Cytoplasmic Vesicle Sperm Midpiece GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Ligase Activity Cysteine-tRNA Ligase Activity ATP Binding Ligase Activity Metal Ion Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Cysteinyl-tRNA Aminoacylation	Autophagosome Assembly Microtubule Cytoskeleton Organization Mitophagy Protein Targeting Autophagy Apoptotic Process Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Autophagosome Maturation Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein K48-linked Ubiquitination
Pathways		Mitochondrial tRNA aminoacylation	Macroautophagy TBC/RABGAPs
Drugs		Cysteine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 26969751) Parkinson's disease ( 34064523)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		7 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B OGT RIPK4	75 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG101 ATG13 ATG3 ATG4B ATG4C ATG4D ATG7 ATXN3 AZI2 BICC1 BIRC6 CARS2 CCT2 CDC37 CUL3 DMPK DVL2 FLCN G3BP1 GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAP4K2 MAPK15 MEFV MIB1 MLH1 MPC1 MTX1 MYBPC1 MYBPC2 NBR1 NCOR1 NEDD4 NEK9 NSF NUFIP2 OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 RESF1 SAMM50 SEC62 SNX18 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28
Entrez ID		79587	11337
HPRD ID		07763	05496
Ensembl ID		ENSG00000134905	ENSG00000170296
Uniprot IDs		B7Z7E6 Q9HA77	O95166 Q6IAW1
PDB IDs			1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 6YOP 7AA8 7BRQ 7BRT 7BRU 7BV4 7EA7 7LSW 7LT6 7VEC 7VED 7YO9 7ZKR 7ZL7 8AFI 8S1M 8T2M 8T2N 8T31 8T32 8T33 8W6A
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Macroautophagy Autophagosome Maturation Autophagosome Membrane Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Autophagosome Organization Autophagy Phospholipid Binding Protein-containing Complex Disassembly Vacuole Organization Cellular Response To Starvation Response To Nutrient Levels Response To Starvation GABA Receptor Binding Organelle Assembly Ubiquitin Protein Ligase Binding Beta-tubulin Binding Microtubule Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Catabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Cellular Component Assembly Regulation Of Protein Localization To Synapse Regulation Of Proteasomal Protein Catabolic Process Regulation Of Receptor Localization To Synapse Organelle Organization Regulation Of Rac Protein Signal Transduction Cellular Response To Stress Endomembrane System Organelle Membrane Response To Stress Negative Regulation Of Proteasomal Protein Catabolic Process Cytosol Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Axoneme Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Autophagosome Autophagosome Assembly Autophagosome Organization Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Autophagy Autophagy Of Mitochondrion Positive Regulation Of Autophagy Regulation Of Autophagy Microautophagy Macroautophagy Positive Regulation Of Catabolic Process Intracellular Protein Localization Mitophagy Organelle Organization Cellular Component Assembly Cytoplasm Organelle Assembly Protein Modification Process Cytosol Positive Regulation Of Metabolic Process Catabolic Process Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex M Band Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Protein Phosphorylation Protein-phosphatidylethanolamide Deconjugating Activity Establishment Of Protein Localization Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Transport Regulation Of Cell Communication Protein Delipidation Phosphorylation Protein Serine/threonine Kinase Activity Protein Kinase Activity Protein Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phagophore Assembly Site Membrane Protein Localization To Organelle Defense Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cell Junction Organization Response To Starvation
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